ID A0A1P8ANE5_ARATH Unreviewed; 909 AA.
AC A0A1P8ANE5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN OrderedLocusNames=At1g56145 {ECO:0000313|Araport:AT1G56145,
GN ECO:0000313|EMBL:ANM58165.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM58165.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM58165.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CP002684; ANM58165.1; -; Genomic_DNA.
DR RefSeq; NP_001320621.1; NM_001333767.1.
DR AlphaFoldDB; A0A1P8ANE5; -.
DR SMR; A0A1P8ANE5; -.
DR EnsemblPlants; AT1G56145.3; AT1G56145.3; AT1G56145.
DR GeneID; 842067; -.
DR Gramene; AT1G56145.3; AT1G56145.3; AT1G56145.
DR Araport; AT1G56145; -.
DR TAIR; AT1G56145; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A1P8ANE5; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48006:SF88; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN KINASE; 1.
DR PANTHER; PTHR48006; LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF11721; Malectin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW Kinase {ECO:0000313|EMBL:ANM58165.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8ANE5,
KW ECO:0007829|ProteomicsDB:A0A1P8ANE5};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:ANM58165.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 525..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..858
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 884..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 100343 MW; DF493E481B0D86C2 CRC64;
MDVAGPIPDD LWTLVYISNL NLNQNFLTGP LSPGIGNLTR MQWMTFGANA LSGPVPKEIG
LLTDLRSLAI DMNNFSGSLP PEIGNCTRLV KMYIGSSGLS GEIPSSFANF VNLEEAWIND
IRLTGQIPDF IGNWTKLTTL RILGTSLSGP IPSTFANLIS LTELRLGEIS NISSSLQFIR
EMKSISVLVL RNNNLTGTIP SNIGDYLGLR QLDLSFNKLT GQIPAPLFNS RQLTHLFLGN
NRLNGSLPTQ KSPSLSNIDV SYNDLTGDLP SWVRLPNLQL NLIANHFTVG GSNRRALPRL
DCLQKDFRCN RGKGVYFNFF VNCGGRDIRS SSGALYEKDE GALGPATFFV SKTQRWAVSN
VGLFTGSNSN QYIALSATQF ANTSDSELFQ SARLSASSLR YYGLGLENGG YSVTVQFAEI
QIQGSNTWKS LGRRIFDIYV QGKLVEKDFD MQKAANGSSI RVIQRVYKAN VSENYLEVHL
FWAGKGTCCI PAQGTYGPLV SAISATPDFI PTVKNKLPSK SKKNIVIIVG AIVGAGMLCI
LVIAILLFIR RKRKRAADEE VLNSLHIRPY TFSYSELRTA TQDFDPSNKL GEGGFGPVFK
GKLNDGREIA VKQLSVASRQ GKGQFVAEIA TISAVQHRNL VKLYGCCIEG NQRMLVYEYL
SNKSLDQALF EEKSLQLGWS QRFEICLGVA KGLAYMHEES NPRIVHRDVK ASNILLDSDL
VPKLSDFGLA KLYDDKKTHI STRVAGTIGY LSPEYVMLGH LTEKTDVFAF GIVALEIVSG
RPNSSPELDD DKQYLLEWAW SLHQEQRDME VVDPDLTEFD KEEVKRVIGV AFLCTQTDHA
IRPTMSRVVG MLTGDVEITE ANAKPGYVSE RTFENAMSFM SGSTSSSWIL PETPKDSSKS
QVEEHGRRH
//
