ID A0A1P8APE5_ARATH Unreviewed; 1389 AA.
AC A0A1P8APE5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=DEAD/DEAH box RNA helicase family protein {ECO:0000313|EMBL:ANM58539.1};
GN Name=FANCM {ECO:0000313|EMBL:ANM58539.1, ECO:0000313|TAIR:AT1G35530};
GN Synonyms=At-FANCM {ECO:0000313|EMBL:ANM58539.1};
GN OrderedLocusNames=At1g35530 {ECO:0000313|Araport:AT1G35530,
GN ECO:0000313|EMBL:ANM58539.1};
GN ORFNames=F15O4.40 {ECO:0000313|EMBL:ANM58539.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM58539.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM58539.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC FANCM sub-subfamily. {ECO:0000256|ARBA:ARBA00009889}.
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DR EMBL; CP002684; ANM58539.1; -; Genomic_DNA.
DR RefSeq; NP_001320965.1; NM_001333164.1.
DR SMR; A0A1P8APE5; -.
DR ProteomicsDB; 199919; -.
DR EnsemblPlants; AT1G35530.5; AT1G35530.5; AT1G35530.
DR GeneID; 840448; -.
DR Gramene; AT1G35530.5; AT1G35530.5; AT1G35530.
DR Araport; AT1G35530; -.
DR TAIR; AT1G35530; FANCM.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A1P8APE5; baseline and differential.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd18033; DEXDc_FANCM; 1.
DR CDD; cd12091; FANCM_ID; 1.
DR CDD; cd18801; SF2_C_FANCM_Hef; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR039686; FANCM/Mph1-like_ID.
DR InterPro; IPR044749; FANCM_DEXDc.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ANM58539.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8APE5};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 122..290
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 448..619
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 39..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 155670 MW; 0B233E9C17BD2FA9 CRC64;
MGSRVPIETI EEDGEFDWEA AVKEIDLACL KTTNASSSSS SHFTPLANPP ITANLTKPPA
KRQSTLDKFI GRTEHKPENH QVVSECGVND NDNSPLVGID PEAAKTWIYP GFVPLRDYQF
AITKTALFSN TLVALPTGLG KTLIAAVVMY NYFRWFPQGK IVFAAPSRPL VMQQIEACHN
IVGIPQEWTI DLTGQTCPSK RAFLWKSKRV FFVTPQVLEK DIQSGTCLTN YLVCLVIDEA
HRALGNYSYC VVVRELMAVP IQLRILALTA TPGSKTQAIQ GIIDNLQIST LEYRNESDHD
VCPYVHDRKL EVIEVPLGQD ADDVSKRLFH VIRPYAVRLK NFGVNLNRDI QTLSPHEVLM
ARDKFRQAPL PGLPHVNHGD VESCFAALIT LYHIRKLLSS HGIRPAYEML EEKLKEGPFA
RLMSKNEDIR MTKLLMQQRL SHGAPSPKLS KMLEILVDHF KVKDPKTSRV IIFSNFRGSV
RDIMNALSNI GDMVKATEFI GQSSGKTLKG QSQKIQQAVL EKFRAGGFNV IVATSIGEEG
LDIMEVDLVI CFDANVSPLR MIQRMGRTGR KNNGRVVVLA CEGSEKNSYM RKQASGRAIK
KHMRNGGTNS FNFHPSPRMI PHVYKPEVQH VEFSIKQFVP RGKKLQEEYA TETPAFQKKL
TPAETHMLAK YYNNPDEEKL RVSLIAFPHF QTLPSKVHKV MHSRQTGMLI DAMQHLQEPT
FSEQSKSFFT EFRAPLGERE ELDTGLRVTN DPKDLHSVRD LEVNTSQRKA KQVESPTSTL
ETTEKDYEES SPTHRYLFSS ECASVDTLGN VFVMPVPLLF FPNVLESDNT PLPKTEKQHS
CRNTSHIDLV PVDTSEKHRQ DNISCKLKER FSPDGASETL ETHSLVKRNS TRVGEDDVAN
SVGEIVLSSD EDDCEGLELS PRLTNFIKSG IVPESPVYDQ GEANREEDLE FPQLSSPMRF
SNELAGESSF PERKVQHKCN DYNIVSTTTE LRTPQKEVGL ANGTECLAVS PIPEDWRTPL
ANLTNTNSSA RKDWRVSSGE KLETLRQPRK LKRLRRLGDC SSAVKENYPG ITEADHIRSR
SRGKKHIRVK WKSAESWFTL SSVAFALVTK KKKMIMDDDV QVFIDEEAEV SSGAEMSADE
NEDVTGDSFE DSFIDDGTMP TANTQAESGK VDMMAVYRYI QPKISFFYCE VNELIKNHKV
SFHRRSLLSQ SPLPARFRDL AASSLSPYSA GPLTRINESR SDSDKSLSSL RTPKTTNSES
NQDAMMIGNL SVVQISSDSR KRKFSLCNSA NAPVINLESK FAAHAQATEK ESHEGVRSNA
GALEYNDDDD DAFFATLDFD AMEAQATLLL SKQRSEAKEK EDATVIPNPG MQRSDGMEKD
APSFDLGLW
//
