ID A0A1P8ASB9_ARATH Unreviewed; 997 AA.
AC A0A1P8ASB9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Leucine-rich repeat protein kinase family protein {ECO:0000313|EMBL:ANM59549.1};
GN Name=VRLK1 {ECO:0000313|TAIR:AT1G79620};
GN OrderedLocusNames=At1g79620 {ECO:0000313|Araport:AT1G79620,
GN ECO:0000313|EMBL:ANM59549.1};
GN ORFNames=F20B17.5 {ECO:0000313|EMBL:ANM59549.1}, F20B17_5
GN {ECO:0000313|EMBL:ANM59549.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM59549.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM59549.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000256|ARBA:ARBA00008684}.
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DR EMBL; CP002684; ANM59549.1; -; Genomic_DNA.
DR RefSeq; NP_001321899.1; NM_001334899.1.
DR AlphaFoldDB; A0A1P8ASB9; -.
DR SMR; A0A1P8ASB9; -.
DR STRING; 3702.A0A1P8ASB9; -.
DR EnsemblPlants; AT1G79620.5; AT1G79620.5; AT1G79620.
DR GeneID; 844301; -.
DR Gramene; AT1G79620.5; AT1G79620.5; AT1G79620.
DR Araport; AT1G79620; -.
DR TAIR; AT1G79620; VRLK1.
DR InParanoid; A0A1P8ASB9; -.
DR OrthoDB; 461482at2759; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A1P8ASB9; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR45974:SF242; LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR45974; RECEPTOR-LIKE PROTEIN 55; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ANM59549.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8ASB9,
KW ECO:0007829|ProteomicsDB:A0A1P8ASB9};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 591..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 664..938
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 970..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 692
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 997 AA; 109244 MW; 0FD69AA49DF5F104 CRC64;
MVGSNTVTAT SRLLLICFAY SFTVFSMISS VTDPRDAAAL RSLMDQWDNT PPSWGGSDDP
CGTPWEGVSC NNSRITALGL STMGLKGRLS GDIGELAELR SLDLSFNRGL TGSLTSRLGD
LQKLNILILA GCGFTGTIPN ELGYLKDLSF LALNSNNFTG KIPASLGNLT KVYWLDLADN
QLTGPIPISS GSSPGLDLLL KAKHFHFNKN QLSGTIPPKL FSSEMILIHV LFDGNRFTGS
IPSTLGLIQT LEVLRLDRNT LTGKVPENLS NLTNIIELNL AHNKLVGSLP DLSDMKSMNY
VDLSNNSFDP SESPLWFSTL PSLTTLVMEY GSLQGPLPNK LFGFPQLQQV RLKKNAFNGT
LSLGDTVGPE LQLVDLQDND ISSVTLSSGY TNTLMYIASF FLNVQSNCLY QPIKEALSCC
RLEGNPVCTT ALSNTNYCQI QQQQVKRIYS TSLANCGGKS CPLDQKVSPQ SCECAYPYEG
TLYFRGPMFR DLSNVNTYHS LEMSLWVKLG LTPGSVSLQN PFFNNDDYLQ IQLALFPPMG
KYFNRTEVQR IGFDLSNQTY KPPPLFGPYY FIASPYTFPA DGNGHSLSSR MVTGIITGCS
ALVLCLVALG IYAMWQKRRA EQAIGLSRPF VSWASSGKDS GGAPQLKGAR WFSYEELKKI
TNNFSVSSEL GYGGYGKVYK GMLQDGHMVA IKRAQQGSTQ GGLEFKTEIE LLSRVHHKNL
VGLVGFCFEQ GEQILVYEYM SNGSLKDSLT GRSGITLDWK RRLRVALGSA RGLAYLHELA
DPPIIHRDVK STNILLDENL TAKVADFGLS KLVSDCTKGH VSTQVKGTLG YLDPEYYTTQ
KLTEKSDVYS FGVVMMELIT AKQPIEKGKY IVREIKLVMN KSDDDFYGLR DKMDRSLRDV
GTLPELGRYM ELALKCVDET ADERPTMSEV VKEIEIIIQN SGASSSSSAS ASSSATDFGE
KLLYGGTLKK KEARDGDGGG AFDYSGGYSV PTKIEPK
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