ID A0A1P8AVS2_ARATH Unreviewed; 409 AA.
AC A0A1P8AVS2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Translation initiation factor eIF2B subunit alpha {ECO:0000256|ARBA:ARBA00044208};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit alpha {ECO:0000256|ARBA:ARBA00044236};
GN OrderedLocusNames=At1g72340 {ECO:0000313|Araport:AT1G72340,
GN ECO:0000313|EMBL:ANM60725.1};
GN ORFNames=T10D10.19 {ECO:0000313|EMBL:ANM60725.1}, T10D10_19
GN {ECO:0000313|EMBL:ANM60725.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM60725.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM60725.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0007829|PubMed:19376835}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [3] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- INTERACTION:
CC A0A1P8AVS2; Q8S8E3: PYL6; NbExp=3; IntAct=EBI-25528474, EBI-2363192;
CC A0A1P8AVS2; Q1ECF1: PYL7; NbExp=3; IntAct=EBI-25528474, EBI-2363203;
CC A0A1P8AVS2; Q84MC7: PYL9; NbExp=3; IntAct=EBI-25528474, EBI-2349513;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; CP002684; ANM60725.1; -; Genomic_DNA.
DR RefSeq; NP_565041.2; NM_105893.4.
DR AlphaFoldDB; A0A1P8AVS2; -.
DR SMR; A0A1P8AVS2; -.
DR IntAct; A0A1P8AVS2; 3.
DR STRING; 3702.A0A1P8AVS2; -.
DR ProteomicsDB; 203964; -.
DR EnsemblPlants; AT1G72340.2; AT1G72340.2; AT1G72340.
DR GeneID; 843566; -.
DR Gramene; AT1G72340.2; AT1G72340.2; AT1G72340.
DR Araport; AT1G72340; -.
DR TAIR; AT1G72340; -.
DR eggNOG; KOG1466; Eukaryota.
DR InParanoid; A0A1P8AVS2; -.
DR OrthoDB; 51607at2759; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A1P8AVS2; baseline and differential.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR Gene3D; 1.20.120.1070; Translation initiation factor eIF-2B, N-terminal domain; 1.
DR InterPro; IPR042528; elF-2B_alpha_N.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45860:SF3; EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR45860; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 1: Evidence at protein level;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8AVS2,
KW ECO:0007829|ProteomicsDB:A0A1P8AVS2};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transferase {ECO:0000313|EMBL:ANM60725.1}.
SQ SEQUENCE 409 AA; 45592 MW; 4AF906346B872BB2 CRC64;
MIFLEKATVY YLQFFHFEEF SQEKKKSMWR RSPSFILDER RSSNSPPMAD TTRGPFQNPD
SISAYYQTRA AHHGVITSDW LAQAQAAVGG VSGDAQHDLS VTDLGNEKSF NVIEEFNNWR
KQPDLAEAVA AIRALAAVIR ASEASTMMEL EIELKKASDT LKSWDKTSIS LTAGCDLFIR
YVTRTSALEY EDFNSAKSRL LERAEKFGEI SCKARRIIAM LSQDFIFDGC TILVHGLSRV
VLEILKTAAQ NNKLFRVLCT EGRPDGTGVL LSSELSKLDI PVKLLLDSAV AYSMDEVDMV
FVGADGVVES GGIINMMGTY QIALVAHSMN KPVYVAAESY KFARLYPLDQ KDMAPALRPI
EFGVKIPTKV EVERSARDYT PPQYLTLLFT DLGVLSPSVV SDELIQLYL
//
