ID A0A1P8AWA3_ARATH Unreviewed; 2021 AA.
AC A0A1P8AWA3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=ATPI4K {ECO:0000313|TAIR:AT1G49340};
GN Synonyms=ATPI4K ALPHA {ECO:0000313|EMBL:ANM60913.1};
GN OrderedLocusNames=At1g49340 {ECO:0000313|Araport:AT1G49340,
GN ECO:0000313|EMBL:ANM60913.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM60913.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM60913.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|EMBL:ANM60913.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ANM60913.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; CP002684; ANM60912.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60913.1; -; Genomic_DNA.
DR RefSeq; NP_001323160.1; NM_001333375.1.
DR RefSeq; NP_001323161.1; NM_001333376.1.
DR SMR; A0A1P8AWA3; -.
DR ProteomicsDB; 179650; -.
DR EnsemblPlants; AT1G49340.3; AT1G49340.3; AT1G49340.
DR EnsemblPlants; AT1G49340.4; AT1G49340.4; AT1G49340.
DR GeneID; 841357; -.
DR Gramene; AT1G49340.3; AT1G49340.3; AT1G49340.
DR Gramene; AT1G49340.4; AT1G49340.4; AT1G49340.
DR Araport; AT1G49340; -.
DR TAIR; AT1G49340; ATPI4K.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A1P8AWA3; baseline and differential.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 1: Evidence at protein level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8AWA3,
KW ECO:0007829|ProteomicsDB:A0A1P8AWA3};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1476..1652
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1727..2005
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 184..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2021 AA; 223347 MW; E84914097E4A0142 CRC64;
MEALTELCDI IAKNPKQFSE KLAWICGRCP QTEWLLAESP RVSRSHLNAV LAVARIISKN
PESIDNRAKS VVNEFLSAIP ASFRRSFWPH SFPSQLISSF YCDFLSYLSC AADLSPEFGT
EVARFTGEVV IAAIAPSSGD SDGDPAISKA FLVALSQHFP SILQSDGDKL ITMLLDQFVL
NRAPASPKEQ RQQNSANSET DTSSSQGSPI STNRYPSGKT EMASPGDEVA SHGSNLSSKS
SSSVVMNGGS IVWKSGVDQL SFGFSEGSGG ANPVFRQQVA SFEDESIESL EKQEIAFRLI
THILDKVKID SKLQDQVRFI AKRQLQSMSA FLKSRKRDWN EQGQVLKTRV NAKLSVYQAA
AKMKIKSLVS LETDGKTSKR LVLETLALLL DAADACLTSV WRKMKACEEL FDSLLSGIAK
IAVARGGQPL RVLLIRLKPL PDQGAMLESI FKTSCVIIES AWAKDRAPVD NFIMGLASSI
RERNDYEEQV DREKQVPAVQ LNVIRLLADL NVAVKKPEVA DMILPLFIES LEEGDASTPS
FLRLQLLDAV SRIATLGFDK SYRETVVLMT RSYLSKLSSV GSVESKTSAP EATTERVETL
PAGFLTIASG LMDTKLRSDY RHRLLSLCSD VGLAAESKSG GSGVDFLGPL LPAVAEICSD
FDPTMDVEPS LLKLFRNLWF YIALFGLAPP IVKTPTPPLK STSNSVNSVG SMSATALQAV
GGPYMWDNQW ALAVQRIAQG TPPLVVSSVK WLEDELELNA LHNPGSRRGN GNEKVASTQR
LALSTALGGR VDVAAMNTIS GVKATYLLAV AFLEIIRFIS NGGILNGESS VSASRSAFSC
VFEYLKTPNL TPAVSQCLTA IVHRAFETAV SWLEDRISLT GKDARNRELT TYAHACFLIK
SMSQRDEHVR DISVNLLTQL RDKFPQVLWH SSCLDSLLFS VHDNTPSTVV NDPAWTAAVR
SLYQKVVREW IIISLSYAPC TSQGLLQDKL CKANTWQRAQ TTTDVVSLLS EIKIGTGKNE
LWSGIRTANI PAVMAAAAAA SGANLKVSEA FNLEVLGTGV VSATVKCNHA GEIAGMRRLY
NSIGGFQSGS TPSGFGGGLQ RLISGAFSQA PQPEDDSFNE MLIARFVRLL QQFVNTAEKG
GEVEKSQFRE TCSQATALLL SNLGGESKTN VEGFSQLLRL LCWCPAYIST PDAMETGIFI
WTWLVSAAPQ LVSLVLAELV DAWIWTIDTK RGLFASDVRY SGPAAKLRPH LSPGEPEDPP
ESDPVDQIVA HRLWLGFLID RFEVVRHNSA EQLLLLGRML QRSTDLEWCF TRHPAAAGTF
FSLMLLGLKF CSCQTQGNMQ KFRSGLQLLE DRIYRTSLGW FAHQPEWYDV NIPNFCHSEA
LSVSVFVHFL SNELSESSQS DSKGKPRESG NLIDVTDQYH PVWGEMDNYT LGKEKRKQLL
LMLCQHEADR LDVWAQPISS KDSPYSRLKI SSEKWTEYAK TAFSVDPRIA LSVASRFPAN
ASVKSEVTQL VQTNIVDLRT IPEALPYFVT PKNVEENSVL LQQLPHWAAC SITQALEFLT
PAYKGHPRVM AYVLRVLESY PPERVTFFMP QLVQSLRYDD GRLVEGYLLR ATQRSDIFAH
ILIWHLQGED VQETPKDGSI DKNAAFQEIL PQVRQHIIDG FSPNALDMFT REFDFFDKVT
SISGVLFPLP KEERRAGIRR ELEKIEMQGD DLYLPTAPNK LVRGIRVDSG IPLQSAAKVP
IMITFNVIDR DGDHSDVKPQ ACIFKVGDDC RQDVLALQVI SLLRDIFQAA GLNLYLFPYG
VLPTGAERGI IEVVPNTRSR SQMGETTDGG LYEIFQQDYG PVGSTTFETA RENFLISSAG
YAVASLLLQP KDRHNGNLLF DDVGRLVHID FGFILETSPG GNMRFESAHF KLSHEMTQLL
DPSGVMKSKT WHQFVSLCVK GYLAARRQMD GIISTVQMML ESGLPCFSRG DPIGNLRKRF
HPEMSEREAA HFMIHVCTDA YNKWTTAGYD LIQYLQQGIE K
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