ID A0A1P8AZN1_ARATH Unreviewed; 144 AA.
AC A0A1P8AZN1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
GN Name=GPX4 {ECO:0000313|EMBL:ANM62105.1, ECO:0000313|TAIR:AT2G48150};
GN Synonyms=ATGPX4 {ECO:0000313|EMBL:ANM62105.1}, glutathione peroxidase
GN 4 {ECO:0000313|EMBL:ANM62105.1};
GN OrderedLocusNames=At2g48150 {ECO:0000313|Araport:AT2G48150,
GN ECO:0000313|EMBL:ANM62105.1};
GN ORFNames=F11L15.5 {ECO:0000313|EMBL:ANM62105.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM62105.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM62105.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S., Shea T.P., Benito M.I., Town C.D.,
RA Fujii C.Y., Mason T., Bowman C.L., Barnstead M., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000256|ARBA:ARBA00006926, ECO:0000256|RuleBase:RU000499}.
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DR EMBL; CP002685; ANM62105.1; -; Genomic_DNA.
DR RefSeq; NP_001324284.1; NM_001337302.1.
DR AlphaFoldDB; A0A1P8AZN1; -.
DR SMR; A0A1P8AZN1; -.
DR ProteomicsDB; 204051; -.
DR EnsemblPlants; AT2G48150.2; AT2G48150.2; AT2G48150.
DR GeneID; 819427; -.
DR Gramene; AT2G48150.2; AT2G48150.2; AT2G48150.
DR Araport; AT2G48150; -.
DR TAIR; AT2G48150; GPX4.
DR OMA; QCGLTKQ; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; A0A1P8AZN1; baseline and differential.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR029759; GPX_AS.
DR InterPro; IPR029760; GPX_CS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592; GLUTATHIONE PEROXIDASE; 1.
DR PANTHER; PTHR11592:SF131; GLUTATHIONE PEROXIDASE 4-RELATED; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000499};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000499};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8AZN1,
KW ECO:0007829|ProteomicsDB:A0A1P8AZN1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT ACT_SITE 18
FT /evidence="ECO:0000256|PIRSR:PIRSR000303-1"
SQ SEQUENCE 144 AA; 16570 MW; B022F8D0C0DD9B7B CRC64;
MSIYQGKVLL IVNVASKCGF TETNYTQLTE LYRKYKDQDF EILAFPCNQF LYQEPGTSQE
AHEFACERFK AEYPVFQKVR VNGQNAAPIY KFLKASKPTF LGSRIKWNFT KFLVGKDGLV
IDRYGTMVTP LSIEKDIKKA LEDA
//
