ID A0A1P8B0Y4_ARATH Unreviewed; 469 AA.
AC A0A1P8B0Y4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN OrderedLocusNames=At2g04080 {ECO:0000313|Araport:AT2G04080,
GN ECO:0000313|EMBL:ANM62579.1};
GN ORFNames=F3L12.9 {ECO:0000313|EMBL:ANM62579.1}, F3L12_9
GN {ECO:0000313|EMBL:ANM62579.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM62579.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM62579.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S., Shea T.P., Benito M.I., Town C.D.,
RA Fujii C.Y., Mason T., Bowman C.L., Barnstead M., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
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DR EMBL; CP002685; ANM62579.1; -; Genomic_DNA.
DR RefSeq; NP_001324727.1; NM_001335215.1.
DR AlphaFoldDB; A0A1P8B0Y4; -.
DR SMR; A0A1P8B0Y4; -.
DR EnsemblPlants; AT2G04080.2; AT2G04080.2; AT2G04080.
DR GeneID; 814944; -.
DR Gramene; AT2G04080.2; AT2G04080.2; AT2G04080.
DR Araport; AT2G04080; -.
DR TAIR; AT2G04080; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; A0A1P8B0Y4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF333; PROTEIN DETOXIFICATION 1-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1P8B0Y4,
KW ECO:0007829|ProteomicsDB:A0A1P8B0Y4};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 469 AA; 50896 MW; 61EFF3B90C6F5A1D CRC64;
MEEPFLPRDE QLVSCKSTWQ SGQVTVELKK VSRLAAPMAT VTIAQYLLPV ISVMVAGHIG
ELELAGVALA TSFTNVSGFS IMFGLVGALE TLCGQAYGAE QYEKIGTYTY SAMASNIPIC
FIISILWIYI EKLLITLGQE PDISRVAGSY SLWLVPALFA HAIFLPLTRF LLAQGLVISL
LYSAMTTLLF HIAVCWTLVF ALGLGSNGAA IAISLSFWFY AVILSCHVRF FSSCEKTRGF
VSNDFMSSIK QYFQYGVPSA GLICLEWWLF ELLILCSGLL PNPKLETSVL SICLTIGTLH
YVIPSGVAAA VSTRVSNKLG AGNPQVARVS VLAGLCLWLV ESAFFSTLLF TCRNIIGYTF
SNSKEVVDYV ADISPLLCLS FILDGLTAVL NGVARGCGWQ HIGALINVVA YYLVGAPVGV
YLAFSREWNG KGLWCGVMVG SAVQATLLAI VTASMNWKEQ VRVCYILVF
//
