ID A0A1P8PZX9_9LACO Unreviewed; 325 AA.
AC A0A1P8PZX9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=PTS system mannose-specific EIIAB component {ECO:0000256|ARBA:ARBA00021685};
DE EC=2.7.1.191 {ECO:0000256|ARBA:ARBA00011929};
DE AltName: Full=EIIAB-Man {ECO:0000256|ARBA:ARBA00032197};
DE AltName: Full=EIII-Man {ECO:0000256|ARBA:ARBA00030229};
GN ORFNames=BTM29_00500 {ECO:0000313|EMBL:APX71119.1};
OS Companilactobacillus allii.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Companilactobacillus.
OX NCBI_TaxID=1847728 {ECO:0000313|EMBL:APX71119.1, ECO:0000313|Proteomes:UP000187499};
RN [1] {ECO:0000313|Proteomes:UP000187499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WiKim39 {ECO:0000313|Proteomes:UP000187499};
RA Jung M.Y., Lee S.H.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II ManXYZ PTS system is involved in mannose transport.
CC {ECO:0000256|ARBA:ARBA00023757}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC mannose 6-phosphate(in) + L-histidyl-[protein]; Xref=Rhea:RHEA:49232,
CC Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:4208,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:58735, ChEBI:CHEBI:64837;
CC EC=2.7.1.191; Evidence={ECO:0000256|ARBA:ARBA00000514};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP019323; APX71119.1; -; Genomic_DNA.
DR RefSeq; WP_076613616.1; NZ_RHNV01000002.1.
DR AlphaFoldDB; A0A1P8PZX9; -.
DR STRING; 1847728.BTM29_00500; -.
DR KEGG; lalw:BTM29_00500; -.
DR OrthoDB; 9788818at2; -.
DR Proteomes; UP000187499; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00006; PTS_IIA_man; 1.
DR CDD; cd00001; PTS_IIB_man; 1.
DR Gene3D; 3.40.50.510; Phosphotransferase system, mannose-type IIA component; 1.
DR Gene3D; 3.40.35.10; Phosphotransferase system, sorbose subfamily IIB component; 1.
DR InterPro; IPR013789; PTS_EIIA_man.
DR InterPro; IPR004701; PTS_EIIA_man-typ.
DR InterPro; IPR036662; PTS_EIIA_man-typ_sf.
DR InterPro; IPR033887; PTS_IIA_man.
DR InterPro; IPR004720; PTS_IIB_sorbose-sp.
DR InterPro; IPR036667; PTS_IIB_sorbose-sp_sf.
DR NCBIfam; TIGR00824; EIIA-man; 1.
DR PANTHER; PTHR33799:SF1; PHOSPHOTRANSFERASE ENZYME IIA COMPONENT YADI-RELATED; 1.
DR PANTHER; PTHR33799; PTS PERMEASE-RELATED-RELATED; 1.
DR Pfam; PF03610; EIIA-man; 1.
DR Pfam; PF03830; PTSIIB_sorb; 1.
DR SUPFAM; SSF52728; PTS IIb component; 1.
DR SUPFAM; SSF53062; PTS system fructose IIA component-like; 1.
DR PROSITE; PS51096; PTS_EIIA_TYPE_4; 1.
DR PROSITE; PS51101; PTS_EIIB_TYPE_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000187499};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..126
FT /note="PTS EIIA type-4"
FT /evidence="ECO:0000259|PROSITE:PS51096"
FT DOMAIN 155..321
FT /note="PTS EIIB type-4"
FT /evidence="ECO:0000259|PROSITE:PS51101"
SQ SEQUENCE 325 AA; 35449 MW; E5ACA6041BE21BB7 CRC64;
MVGIIIASHG EFAKGIKQSG SMIFGEQEEV QAVTLMPDMG PDDLKAKLEE AIATFKDQDQ
VLFLVDLWGG TPFNQVNGLF EAHKDKWAIV AGLNLPMLIE AYASRLSMDS AHEIAAHILE
TAKDGVKVRP EELQPKEAAK PATSEQQVAN TGKPGSFKYV LSRIDSRLLH GQVATAWSKS
VTPTRIIVVS DAVAKDDLRT QLIQQAAPVG VKAHVVPVDQ MIKLAKDDKH FGGQRALLLF
ETPQDALRAI EGGVPLKELN VGSMAHSAGK VQPNKVLAFD QNDIDTFKKL EDKGIKFDVR
KVPTDSQDNM DSILNKAQAE LNKNK
//
