ID A0A1P8Q588_9LACO Unreviewed; 758 AA.
AC A0A1P8Q588;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:APX73017.1};
GN ORFNames=BTM29_10850 {ECO:0000313|EMBL:APX73017.1};
OS Companilactobacillus allii.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Companilactobacillus.
OX NCBI_TaxID=1847728 {ECO:0000313|EMBL:APX73017.1, ECO:0000313|Proteomes:UP000187499};
RN [1] {ECO:0000313|Proteomes:UP000187499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WiKim39 {ECO:0000313|Proteomes:UP000187499};
RA Jung M.Y., Lee S.H.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP019323; APX73017.1; -; Genomic_DNA.
DR RefSeq; WP_076617511.1; NZ_RHNV01000006.1.
DR AlphaFoldDB; A0A1P8Q588; -.
DR STRING; 1847728.BTM29_10850; -.
DR KEGG; lalw:BTM29_10850; -.
DR Proteomes; UP000187499; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187499};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 489..695
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 758 AA; 86788 MW; 9FF2EC85976C9442 CRC64;
MIKDLLIFPA LIGCLAVALV FNTHEYALLL LMILIFIRII LLKNVKLLLL ALIVGGFMTG
YAQFQLHSIP RIPDNVTKLY IASDDIKVSG DLLSSIASDD KQKFKVYYRI PDEREKRFWT
NLNNVVEVRI KTKNIETIKE ARNPGEFDYA KYLQHRKIYY GITIDKFEQT NIKTNLSIKD
KINVLRIHLI QKFNKLPKWL KIHAHSLLLG YNDNADENLF SNLSTLGIIH LFSLSGLHVL
IFLSIFRKIC SFLRITREFV DLSMLFMLPL YGILVGSKPG IWRAIILAIV GIILQKMNIT
CSKTDIFGLT IFFCLLLNPY SLMDMGGQLS FLLSFSLLFI NSGNVIVQTL KINLVSLPLI
LFKTYQFSWL ILLANLVFVP IFEYIILPVT LISAIFVESG MLFWNLFNNL FDRIYSMIAL
FSSNDTYSLI TGTLPVAIVF ILTFVALFII ESKFLINRYL VSYLIILCFA IFLNKHPISG
QVSIIDVGQG DSILITTPLN RKTYLVDTGG KLDFPKKEWQ KRKQLNQVEV STIPYLKQHG
ISKIDKVFLS HKDVDHIGNL ETLIKKFPVD EIDFGTGLEE NFRIYQIIKD NPKIKFNKFH
TGDRFRDGNI DWNIIWPKDK SIGENGDSLT ILANIQGNNW LFTGDLDIEG EKKILASQKF
DVDYLKVGHH GSKTSSGYDF IKSISPKMAL ISAGVNNRYG HPNKETIETL DKLHVPHMNT
AEYGMITWYY YPFSNKNKIT TFLKGEVVED SRINTKAK
//
