ID A0A1P8UHN6_9GAMM Unreviewed; 371 AA.
AC A0A1P8UHN6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Intermembrane phospholipid transport system permease protein MlaE {ECO:0000256|ARBA:ARBA00020857};
GN ORFNames=BW247_09840 {ECO:0000313|EMBL:APZ43355.1};
OS Acidihalobacter ferrooxydans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Acidihalobacter.
OX NCBI_TaxID=1765967 {ECO:0000313|EMBL:APZ43355.1, ECO:0000313|Proteomes:UP000243807};
RN [1] {ECO:0000313|EMBL:APZ43355.1, ECO:0000313|Proteomes:UP000243807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V8 {ECO:0000313|EMBL:APZ43355.1,
RC ECO:0000313|Proteomes:UP000243807};
RA Khaleque H.N., Ramsay J.P., Murphy R.J.T., Kaksonen A.H., Boxall N.J.,
RA Watkin E.L.J.;
RT "Draft sequence of Acidihalobacter ferrooxidans strain DSM 14175 (strain
RT V8).";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex MlaFEDB, which is
CC involved in a phospholipid transport pathway that maintains lipid
CC asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. Probably
CC responsible for the translocation of the substrate across the membrane.
CC {ECO:0000256|ARBA:ARBA00002460}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MlaF),
CC two transmembrane proteins (MlaE), two cytoplasmic solute-binding
CC proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).
CC {ECO:0000256|ARBA:ARBA00011380}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU362044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362044}.
CC -!- SIMILARITY: Belongs to the MlaE permease family.
CC {ECO:0000256|RuleBase:RU362044}.
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DR EMBL; CP019434; APZ43355.1; -; Genomic_DNA.
DR RefSeq; WP_076836996.1; NZ_CP019434.1.
DR AlphaFoldDB; A0A1P8UHN6; -.
DR STRING; 1765967.BW247_09840; -.
DR OrthoDB; 9810518at2; -.
DR Proteomes; UP000243807; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR003453; ABC_MlaE_roteobac.
DR InterPro; IPR030802; Permease_MalE.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00056; MlaE family lipid ABC transporter permease subunit; 1.
DR PANTHER; PTHR30188:SF3; ABC TRANSPORTER PERMEASE PROTEIN; 1.
DR PANTHER; PTHR30188; ABC TRANSPORTER PERMEASE PROTEIN-RELATED; 1.
DR Pfam; PF02405; MlaE; 1.
DR Pfam; PF13466; STAS_2; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU362044};
KW Cell membrane {ECO:0000256|RuleBase:RU362044};
KW Membrane {ECO:0000256|RuleBase:RU362044};
KW Reference proteome {ECO:0000313|Proteomes:UP000243807};
KW Transmembrane {ECO:0000256|RuleBase:RU362044};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362044}.
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 195..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 308..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 351..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT DOMAIN 1..93
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 371 AA; 39299 MW; 506077FCBC3256CC CRC64;
MSHGTPTLRT EGAVVHLGGS WIAAQLRNLD GKTLQRAMPH DSALTLDLGA VDTLDTSGAW
LIQRLLLDLR AAGRDVTTQH ANPNIAALLE LIGAQNDPRA HSGARRPPGL LETVGRASLG
TLRTAYEFLS FLGEGALTTL RATAMPRHLR PRMLLKTIEQ AGVNALPIIG LLSFLIGVVI
AYQSALFLRQ YGANIYLADL VGISMVRELA PLMTAIIVAG RTGSAFTAQI GTMMVTEEVD
ALRAMGIRPL EILFIPKVLG LMIALPLLTL FADVMGVLGG AVIGQTVLGI SPHAYFDELI
QAVSVSSYLV GLSKTPVFAV VIATVGCYQG FKVRGSAESV GQRTTLSVVQ AIFLVIVIDA
AFSIIFNGLG L
//
