ID A0A1P8UL42_9GAMM Unreviewed; 655 AA.
AC A0A1P8UL42;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:APZ44550.1};
GN ORFNames=BW247_04720 {ECO:0000313|EMBL:APZ44550.1};
OS Acidihalobacter ferrooxydans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Acidihalobacter.
OX NCBI_TaxID=1765967 {ECO:0000313|EMBL:APZ44550.1, ECO:0000313|Proteomes:UP000243807};
RN [1] {ECO:0000313|EMBL:APZ44550.1, ECO:0000313|Proteomes:UP000243807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V8 {ECO:0000313|EMBL:APZ44550.1,
RC ECO:0000313|Proteomes:UP000243807};
RA Khaleque H.N., Ramsay J.P., Murphy R.J.T., Kaksonen A.H., Boxall N.J.,
RA Watkin E.L.J.;
RT "Draft sequence of Acidihalobacter ferrooxidans strain DSM 14175 (strain
RT V8).";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
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DR EMBL; CP019434; APZ44550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P8UL42; -.
DR STRING; 1765967.BW247_04720; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000243807; Chromosome.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000243807};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 36..321
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 330..648
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 655 AA; 73586 MW; 52664539EC672EAF CRC64;
MEKPYEWTGL RSDFATEGDD ATARVNNDTA LEHGLERAIS ALTHDQHADG YWCYELEADC
TIPAEYILMM HFMDEIDAPL QERMARYLRR HQNEDGGWPL FEGGPADISC TVKAYYALKL
AGDLPDAPHM RRARDCVLAA GGAARANVFT RIALAQFGQV PWRAVPFTPI EVMLFPRWFA
FHLSKVAYWS RTVMVPLLIL CSLKRMARNP HGIGVRELFI TAPEEETDYF PVRSAANRVL
IRLDAVGRRA ERFIPRWLRR RAIARGEAWF TARLNGHGGL GAIFPAMVNA YEALDCLGYP
ADHPYRRTAR EAIDKLLIEH ADEAYCQPCV SPVWDSVLAA LALQETGQAR AIDAAERALQ
WLAGEQLLDA PGDWREQHPT LPGGGWAFQF RNDYYPDLDD TGAVGWAMYR SADARYTEAR
ERAARWVAGM QSSNGGYGAF DADNTHDYLN EIPFADHGAL LDPPTADVSA RCAILLNYAS
RENPAYREPL SRVLEYLYAQ QEEDGAWFGR WGTNYIYGTW SVLAALEVCG VDPQHPAIRR
AVAWLKRAQR ADGGWGETNL SYFEPELRGQ ADASTSFHTA WALLGLMAAG EAHAPEARRG
IDHLLATQDT EGLWHEPQFS APGFPRVFYL KYHGYSKYFP LWALARYRTL TGSAA
//
