ID A0A1P8USR2_9RHOB Unreviewed; 343 AA.
AC A0A1P8USR2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:APZ52440.1};
DE EC=1.1.1.95 {ECO:0000313|EMBL:APZ52440.1};
GN ORFNames=Ga0080574_TMP2106 {ECO:0000313|EMBL:APZ52440.1};
OS Salipiger abyssi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Salipiger.
OX NCBI_TaxID=1250539 {ECO:0000313|EMBL:APZ52440.1, ECO:0000313|Proteomes:UP000187059};
RN [1] {ECO:0000313|EMBL:APZ52440.1, ECO:0000313|Proteomes:UP000187059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2014 {ECO:0000313|EMBL:APZ52440.1,
RC ECO:0000313|Proteomes:UP000187059};
RA Tang K.;
RT "Deep-sea bacteria in the southern Pacific.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP015093; APZ52440.1; -; Genomic_DNA.
DR RefSeq; WP_076698577.1; NZ_CP015093.1.
DR AlphaFoldDB; A0A1P8USR2; -.
DR STRING; 1250539.Ga0080574_TMP2106; -.
DR KEGG; paby:Ga0080574_TMP2106; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000187059; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd12175; 2-Hacid_dh_11; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000187059}.
FT DOMAIN 42..107
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 121..295
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 343 AA; 37450 MW; 2C9C18FEFEC2AA4B CRC64;
MAPKIYIARD PVLEEVLDSA SAKLAEKGWE VIRGPEVVPG VPRRLSEEER AALLTDVDLI
VASSRSRLSE ADLDASPRLR ALVFPTIGVD AVDLEACASR GLLVANGATP ENFLAMSEAT
VMLMLVLLYR LHESERLLRE NAPRPQVMYG RMLRGRTVGL IGSGRIGGGV IARLAAWEPA
EILVHDPFLP PETAPAGVRL VGRDELLEKA DVISLHVPLN DETRGMLGEA ELRQMKPDAI
LVNTSRGGLI DEDALVRVMR DGHLAGAGLD VTETEPLPMD HPLRSLDRVI LTPHILGHTI
DLYTVMPEVL VENATRLMAG DLPLYTRNPG VEPDWRKRLD SIG
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