ID A0A1P8XQ22_9ACTN Unreviewed; 672 AA.
AC A0A1P8XQ22;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acetoacetate--CoA ligase {ECO:0000313|EMBL:AQA10306.1};
GN ORFNames=BV401_07195 {ECO:0000313|EMBL:AQA10306.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:AQA10306.1, ECO:0000313|Proteomes:UP000187851};
RN [1] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP019458; AQA10306.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P8XQ22; -.
DR STRING; 75293.BV401_07195; -.
DR KEGG; sauo:BV401_07195; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AQA10306.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 52..108
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 117..485
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 552..627
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 672 AA; 73752 MW; 650BB37DC0C19A35 CRC64;
MTTAAQPDHR PHPLWQPGTD RIARSRLTAF HAWAAERHGA PAPGPDDPTA SYAALHRWSV
EELETFWQAV AEWFEVRFAT PYERVLADAA MPGARWFPGA TLNYAEHALR AAEDPARADE
PALLYVDEIH EPRPVSWAEL RGQVGAVAAE LRRLGVRPGD RVSGYVPNIP QATVALLATA
AVGAVWTSCA PDFGARSVLD RFQQVEPVVL FTIDGYRYGG KTHDRTATVS ELRAELPSLR
AVVHIPLLGT PAPEGALAWD DIVRDAIDPV FEQLPFDHPL WVLYSSGTTG LPKAIVQSQG
GILLEHLKQL GLHCDLGPDD RFFWYTSTGW MMWNFLVSGL LVGATVVLYD GSPGHPDTAA
QWRVAERTGT TLYGTSAAYV MACRKADVHP GRDFDLSRVK CVATTGSPLP PDGFRWIHDE
VAEDMWIASV SGGTDVCSCF AGAVPTLPVY IGELQAPGLG TDLQAWDPQG HPVIDEVGEL
IVAQPMPSMP VRFWNDPDGS RYRDSYFEMF PGAWRHGDWI TLTSRGTVVI HGRSDSTLNR
QGVRMGSADI YEAVERLPEI RESLVIGVEQ PDGGYWMPLF VHLAPGATLD EALLTRIKTT
IRTQLSPRHV PDEVIEVPGV PHTLTGKRIE VPVKRLLQGT SLDKAVNPGS VDNVELLRYY
ERLARERGGT GA
//
