ID A0A1P8XWP7_9ACTN Unreviewed; 648 AA.
AC A0A1P8XWP7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Histidine kinase domain-containing protein {ECO:0000259|PROSITE:PS50109};
GN ORFNames=BV401_21580 {ECO:0000313|EMBL:AQA12648.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:AQA12648.1, ECO:0000313|Proteomes:UP000187851};
RN [1] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP019458; AQA12648.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P8XWP7; -.
DR STRING; 75293.BV401_21580; -.
DR KEGG; sauo:BV401_21580; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 468..646
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 71..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 66961 MW; 9D1752D117C08B5B CRC64;
MVVGVINTRW TPIRRRRSAS ALAEVTQHIL AGETADATLR LIARRVRELL GADMARVMVL
EPGDVLTIRA TDGAPWTAPS GPLTPGGSSP ARQAIRAGRP TVSGDERRPR RRGRDPRHAV
PASVLDAPLL VRGHPVGVIE VANRGGGRVL THADVSTVGL FAAAAGHAVA QIRHREHLRR
LASAAAGPGA SCSGSSGPSG LPEASGFAGA SGASGASAPS GASGLLGPSG RSASSGLPGA
SGPSVLPGPA GPSAAPWGTP VSPRPSGPSV RRTLDSLAAG AVARTGAASC TVYLLEPGPS
ANLRLVGGGH GHTPPSRKPA LEAIAGAAPV IHGGGRTGAD GEGPARGAVA AWPLLRESTA
IGAMCCHFPP GRDPGEADIT LLEVIAGHAS CAVENDRQRG ATQEKAVHEE RQRISRELHD
SVSQALYGIA LGARTAREML ERDIDSAEPV ERTEPVSRVE MAGRTDPAAV HETVAEVVDL
AELAELAEPI EYIRRLADAA IAETRTLLCR LRPESLETEG LVAALTQHVE ALRARYGIAT
EAKLDAEPET TPEAKHALYR IAQESLHNVA KHSQARNVRL HLLSEPGAIT LTVADDGVGF
DCKGSFPGHL GLLSMRERAR EVGGTLNVDS RPGQGSRIRA RVPATPDP
//
