ID A0A1P8XZT4_9ACTN Unreviewed; 358 AA.
AC A0A1P8XZT4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:AQA13685.1};
GN ORFNames=BV401_27930 {ECO:0000313|EMBL:AQA13685.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:AQA13685.1, ECO:0000313|Proteomes:UP000187851};
RN [1] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP019458; AQA13685.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P8XZT4; -.
DR STRING; 75293.BV401_27930; -.
DR KEGG; sauo:BV401_27930; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AQA13685.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 5..235
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 311..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 37557 MW; 2BB949A97709E65C CRC64;
MPGAIHAEGL VKTFGDVRAL DGVDLDVPEG TVLGLLGPNG AGKTTAVRVL TTLLRPDSGR
AVVAGVDVLK NPDEVRRSIG LSGQFAAVDE YLTGRENLRM VGQLYQMGAR AARARASELL
ERFGLAEAAD RTAKTYSGGM RRRLDLAAAL VVRPPVMFMD EPTTGLDPRN RQALWEVIQE
LVAGGTTLLL TTQYLEEADH LAHDICVIDR GRVIARGTSD QLKARTGGER VEVVVHEREH
IAAADEVLRV LGKGETTVQE HTRKVTVPVV GGAKLLAEVI RELDTRGVEI DDIGLRRPTL
DDVFISLTGR GTDDGLRGGG GTEDGLRGDG GAEGGLRGGG GAEGGLRGGG GAEGGGGE
//
