ID A0A1P8Y8R3_9ACTN Unreviewed; 1508 AA.
AC A0A1P8Y8R3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=BV401_38420 {ECO:0000313|EMBL:AQA16782.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:AQA16782.1, ECO:0000313|Proteomes:UP000187851};
RN [1] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; CP019458; AQA16782.1; -; Genomic_DNA.
DR STRING; 75293.BV401_38420; -.
DR KEGG; sauo:BV401_38420; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.60.120.1060; NPCBM/NEW2 domain; 1.
DR InterPro; IPR018905; A-galactase_NEW3.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR013222; Glyco_hyd_98_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR038637; NPCBM_sf.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF08305; NPCBM; 1.
DR Pfam; PF10633; NPCBM_assoc; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00776; NPCBM; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AQA16782.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 640..774
FT /note="LamG-like jellyroll fold"
FT /evidence="ECO:0000259|SMART:SM00560"
FT DOMAIN 958..1227
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
FT DOMAIN 1357..1502
FT /note="Glycosyl hydrolase family 98 putative carbohydrate-
FT binding module"
FT /evidence="ECO:0000259|SMART:SM00776"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1335..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 163413 MW; 43D7AD55A1DD9B43 CRC64;
MALALTVPTA PAAAADPKDP PADVYQLLED PEVTSVGQEP AHARLTPYAD TAEALGGGSR
SRWTASLDGT WKLHMSDRPE EVPKDFFTEG YDTSEGGWRS VSVPHTWQTD GLDHPMFRNI
PTEMYPDDPP KVPHDVNPTG AYVKTFELPE SWEKRRTFLR FEGVTSGYLV WVNGSYAGYD
QGGYTPAEFD ISDRLHPGRN TVAVQVHRWG SGSHLEDYDQ WRFSGIFRSV GLYSTPATYL
RDITVKTDLD ARYRDARLTA EVDIAAKGPK TPDRAPDGRK VLGTLYDQRG HKVTTMSGTV
DGDSGSTVLT AHVANPAKWT DETPHLYTLV VRLTDADGTV THTTAQPVGF REIEIKDRQL
LVNGERILVK GVNRSETDPD TGRHATRERT ASDVALMKRL NINSVRTSHY PSDPYLYELA
DARGLWIDDE VDIETHHHDA CPDNCLAERP EWQAAFLDRL MAMYERDKNH PSVLMWDTGN
EAGLGKAHYA MADFLDREDP ARPVYHQPNS PDGDAPFADV WGPRYPSPAS LADKAKTTTK
PIIMGEYAHA MGNSLGNFRE FWDVVRKYPQ VQGGYIWDWA EQNITQPLLT TPDTSGNDIL
SYVSGKPGLV AGHRGRALEL SGLDDFVEVY RDPKLDAVSD ALTLDAWVKP ADWTGSFTVI
AKGDHSYALK MRDKDTLEFF VHGDGDWHTV AADVPDGWYG SWHRVSGTFD GRTLRLLIDG
KQTASADWTG SVDHSAQPVN IGRNPETEQE NIGTRMAHGT VDQVRVYHKA LSPDQLAADP
RADAVLALDF DRLDRKGEFL SYGAGTGGVD GVVSSDRTVQ PEARAMAAVH APIRISGDEA
RAGRVEVRNE RSFTGTDDLR LRWRVTEGAR TLTRGSRTLD LGPGQHTTLQ LPKPPANPRD
ADRQLTVEAV WASDTAWAKA GERVAVEQFD IGGRQLAGTV PARAPGKVRA TTSGGRLTVT
GEGFSYGFDR TSGELVSMKA DGRELLGSGP ELDAWRAPVS NEIGSEEGPW RDAGLDRLRT
EPGKVTVAER GGEVVVTVPS SAAAPGVRDS SFAQTLRYTV SGTGELRLDH RVEARGAARA
VPYLPRLGLS LRVPDRYDRF TWYGRGPQEN YNDREDGAPV GVYSTDVDEQ FAGYTKPQDY
GNHEDVRWAS LSDGSSGLLV SGDFSAGVTP YTGIDRAAYP FALREDPEGN TLHLDHAVSG
VSETFHTVLP EYQVRPAKEY AYTLRLRPLT GAEARTGTPH GPVVCAPEAK LTPADTTVPA
GGSTSAELTV TNPCDTPLRE VTAAFGLPEG WTATPGTLDL GDLAAGRTAT VRTELTRGEG
TPNGPRPAVA EVRATSTGGA RVSGSASAEI DGTPPPPRGE VSVSTLDFLT ADNGWGPVER
DRSNGEDAPG DGKTLTIDGT TYERGLGTHA DSTVEVFLGG NCSTFTATTG LDDEVGADGS
VVFEVYADGE RVYRGETAHG SDAAVPVEAR IEGARKLRLR VTDGGDGNAH DHADWAAATV
RCGTGGTG
//
