ID A0A1Q1PN20_9VIRU Unreviewed; 436 AA.
AC A0A1Q1PN20;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Papain-like cysteine protease {ECO:0000313|EMBL:AQM73145.1};
GN ORFNames=NMV_164 {ECO:0000313|EMBL:AQM73145.1};
OS Noumeavirus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Marseilleviridae; Marseillevirus.
OX NCBI_TaxID=1955558 {ECO:0000313|EMBL:AQM73145.1, ECO:0000313|Proteomes:UP000203865};
RN [1] {ECO:0000313|EMBL:AQM73145.1, ECO:0000313|Proteomes:UP000203865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMV1 {ECO:0000313|EMBL:AQM73145.1};
RA Fabre E., Santini S., Legendre M., Bruley C., Coute Y., Claverie J.-M.,
RA Abergel C., Jeudy S.;
RT "The proteome of Melbournevirus and Noumeavirus virions unveil a nucleo-
RT cytoplasmic infectious cycle of Marseilleviridae.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KX066233; AQM73145.1; -; Genomic_DNA.
DR Proteomes; UP000203865; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:AQM73145.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:AQM73145.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 414..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..315
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 436 AA; 49505 MW; 27D9E69D3B019C08 CRC64;
MDLSKFATET PRPSFTVLRA DSKAVEQYYT NTNPKTSSLE SLEKELPEFF DGRKKWNGLL
SRPLNQGNCG ACWSFSSTSS MADRFAIFSG GQIKFVASPS KPIVCDYHPT VADLSSQQTI
RKLNEKFIKD GACHGNSLPE SFEYLYVYGT TTLGCFPYTF ANYTSSEKLP FCVDLLGEKL
DHCPSGVPMQ IFRVKMPYFV QRKEKRDTTD KDLMAEIYQR GPVSCGYVVY KDFMFPKDYP
NSWREGVYKH DAKVEEIMGG HAIVVVGWGT SKSGRGYWII RNSWGEDWGD DGYFLMERNC
PFANLEQNNM TCIPDIPGLV LPDELQERYL NSNFHKALRE TFPLHESGFP MSIVSQMSEQ
QQRWLKPLVL PGSLPDLKTF IAAKMPNPLE IPGAEDNPRE TFEYTEKGSL GNSWLFFLVI
LLGLFVVVLA LYATKK
//
