ID A0A1Q2CI43_9ACTN Unreviewed; 317 AA.
AC A0A1Q2CI43;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=GDP-mannose 4,6-dehydratase {ECO:0000313|EMBL:AQP45743.1};
DE SubName: Full=UDP-glucose 4-epimerase {ECO:0000313|EMBL:SDZ12411.1};
GN ORFNames=RPIT_13780 {ECO:0000313|EMBL:AQP45743.1}, SAMN05428934_11144
GN {ECO:0000313|EMBL:SDZ12411.1};
OS Tessaracoccus flavus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=1610493 {ECO:0000313|EMBL:AQP45743.1, ECO:0000313|Proteomes:UP000188324};
RN [1] {ECO:0000313|EMBL:AQP45743.1, ECO:0000313|Proteomes:UP000188324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RP1T {ECO:0000313|EMBL:AQP45743.1,
RC ECO:0000313|Proteomes:UP000188324};
RX PubMed=26869509; DOI=10.1099/ijsem.0.000958;
RA Kumari R., Singh P., Schumann P., Lal R.;
RT "Tessaracoccus flavus sp. nov., isolated from the drainage system of a
RT lindane-producing factory.";
RL Int. J. Syst. Evol. Microbiol. 66:1862-1868(2016).
RN [2] {ECO:0000313|EMBL:SDZ12411.1, ECO:0000313|Proteomes:UP000199635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RP1 {ECO:0000313|EMBL:SDZ12411.1,
RC ECO:0000313|Proteomes:UP000199635};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AQP45743.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RP1T {ECO:0000313|EMBL:AQP45743.1};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; CP019605; AQP45743.1; -; Genomic_DNA.
DR EMBL; FNPU01000011; SDZ12411.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2CI43; -.
DR STRING; 1610493.RPIT_13780; -.
DR KEGG; tfl:RPIT_13780; -.
DR OrthoDB; 9801785at2; -.
DR Proteomes; UP000188324; Chromosome.
DR Proteomes; UP000199635; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000188324}.
FT DOMAIN 3..238
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 317 AA; 33413 MW; 89A91A76075BBB18 CRC64;
MKVLVTGGAG FIGSNLARAM LAAGSFEEVR VLDDLSTGYA ENLTGLDVAF TEGSILDMAA
LERVADGVDS IVHLAAIPSV PRSVANPRAS HDANATGTLN VLEAARATGV EQVIVASSSS
VYGSNPTLPK NEDDWTRPLS PYAVSKLATE GYAIAYQASY GLKTLPFRFF NVYGPGQAAG
HAYAAVVPKF IDAALSGQAL EIHGDGRQSR DFTFVADVCR VIMSAVSRRL SHPGPVNLAF
NTNTTLLELI SELEAQLGET VAKEFTDPRV GDVRASQADS LLLRELFPDV TPLPLADGLS
ATLAWYRGRI GLDTGAS
//
