UniProt: A0A1Q2D3F2

Database: UniProt
Entry: A0A1Q2D3F2_9ENTE

LinkDB:  A0A1Q2D3F2_9ENTE 
Original site:  A0A1Q2D3F2_9ENTE

All links

Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (22)   
   InterPro (14)   
   Pfam (3)   
   PROSITE (1)   
   SMART (4)   
Literature (1)   
   PubMed (1)   
All databases (32)   

Download RDF

ID   A0A1Q2D3F2_9ENTE        Unreviewed;       883 AA.
AC   A0A1Q2D3F2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   ORFNames=BW732_00775 {ECO:0000313|EMBL:AQP52900.1}, CBF34_06940
GN   {ECO:0000313|EMBL:RSU01389.1};
OS   Vagococcus penaei.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Vagococcus.
OX   NCBI_TaxID=633807 {ECO:0000313|EMBL:AQP52900.1, ECO:0000313|Proteomes:UP000188246};
RN   [1] {ECO:0000313|EMBL:AQP52900.1, ECO:0000313|Proteomes:UP000188246}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD276 {ECO:0000313|EMBL:AQP52900.1,
RC   ECO:0000313|Proteomes:UP000188246};
RX   PubMed=19897618; DOI=10.1099/ijs.0.012872-0;
RA   Jaffres E., Prevost H., Rossero A., Joffraud J.J., Dousset X.;
RT   "Vagococcus penaei sp. nov., isolated from spoilage microbiota of cooked
RT   shrimp (Penaeus vannamei).";
RL   Int. J. Syst. Evol. Microbiol. 60:2159-2164(2010).
RN   [2] {ECO:0000313|EMBL:AQP52900.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CD276 {ECO:0000313|EMBL:AQP52900.1};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RSU01389.1, ECO:0000313|Proteomes:UP000286995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 24833 {ECO:0000313|EMBL:RSU01389.1,
RC   ECO:0000313|Proteomes:UP000286995};
RA   Gulvik C.A.;
RT   "Vagococcus spp. assemblies.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SUBUNIT: Single-chain monomer with multiple functions.
CC       {ECO:0000256|ARBA:ARBA00011541, ECO:0000256|RuleBase:RU004460}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP019609; AQP52900.1; -; Genomic_DNA.
DR   EMBL; NGJV01000012; RSU01389.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q2D3F2; -.
DR   STRING; 633807.BW732_00775; -.
DR   KEGG; vpi:BW732_00775; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000188246; Chromosome.
DR   Proteomes; UP000286995; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000188246};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          4..267
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          306..473
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   DOMAIN          639..847
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   883 AA;  100994 MW;  062B13594DA6EF2C CRC64;
     MEKKKLLLVD GNSVAFRGFF ALYQSLERFK NKHGLHTNAL YAVNNMLENI LEAEKPTHAL
     IAFDAGKTTF RHAFYDEYKG GRSKTPSEFK EQMPYLRDLI EGFGLQHYEL ANYEADDIIG
     TLAKQVASDE YEVVILTGDK DLLQLADDHI TVKVTVKGVS EIESYTPEHI KEKYTLTPEQ
     IVDMKGLAGD QSDNIPGVTK IGEKTAIKLL TQFGTVEGVY EHIDDLKKSK MKENLINEKE
     TALLSKRLAK IDTQSPITIS VDELDYKGKN LDKLVSFYQE MDFNSFLAKL DTSSIDIPVE
     KKEDIVYTLV DVPTEEMFQS DMSLYIEMLE DNYHTSPIIG VAWGKQNHLY VATDDLIFDH
     PLFKQWIENV DMTKKTYDMK RTYVALRRYN QQLKQVKFDA LLAAYIVDST NNSDDVAEVS
     EKFGYHDVDR DEVIYGKGAK KGIPDDMSVF AEHLARKVLA IDYLYDKLSS ELEEKEQVDL
     FYQMELPLAK ILADMEIEGI TVDASRLVAM KGEFAERLKE IEQKVYTEAG EEFNLNSPKQ
     LGVILFEKMK LPVIKKTKTG YSTAVDVLEK LQHEAPIIDY ILEYRQLAKI QSTYVEGLLK
     VIFADHKIHT RYLQTLTQTG RLSSVDPNLQ NIPIRLEEGR KIRQAFVPRQ KGWKLFSSDY
     SQIELRVLAH ISNDEHLKQA FINGEDIHAA TAMRVFDIAN PEDIDGNTRR QAKAVNFGVV
     YGISDYGLSQ NLGISRKEAK AFIDRYFEKY PGVKTYMESI VRDAKELGYV ETLYHRRRYL
     PDINSRNFNL RSFAERTAIN TPIQGSAADI LKIAMIKISE RLKEENMQAT MLLQVHDELV
     FEAPEEEIEK LQQLVEETMA HAVDLHVPLL ADSSVGDTWY DAK
//

DBGET integrated database retrieval system