ID A0A1Q2GZC3_9GAMM Unreviewed; 718 AA.
AC A0A1Q2GZC3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN ORFNames=B0W48_12155 {ECO:0000313|EMBL:AQQ00484.1};
OS Pseudoalteromonas aliena.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=247523 {ECO:0000313|EMBL:AQQ00484.1, ECO:0000313|Proteomes:UP000188243};
RN [1] {ECO:0000313|EMBL:AQQ00484.1, ECO:0000313|Proteomes:UP000188243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EH1 {ECO:0000313|EMBL:AQQ00484.1,
RC ECO:0000313|Proteomes:UP000188243};
RA Kim E., Heo E., Kim H., Kim D.;
RT "Complete genome sequence of the cold-active Pseudoalteromonas aliena
RT strain EH1 isolated from Arctic seawater.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CP019628; AQQ00484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2GZC3; -.
DR STRING; 247523.B0W48_12155; -.
DR KEGG; paln:B0W48_12155; -.
DR Proteomes; UP000188243; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:AQQ00484.1};
KW Transferase {ECO:0000313|EMBL:AQQ00484.1}.
FT DOMAIN 393..454
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 644..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 718 AA; 80658 MW; 6136896EE633A50D CRC64;
MVATRQSHQQ DETGDFATRL KELGLSAEKA ELLNQAQALC VNCNNEKQQN TAIEMVEILA
ELNLDAESLA TAYLTPYFLN DVVLLDTVEE LLGNNVAILL TGVAQMATIS TLSHQGKGSV
QVDNIRKMLL TMVEDVRAVV IKLAEQVCHL RNVKDADEED RVIAAKETAD IFAPLANRLG
IGQLKWELED LSFRYLRPDI YKSIAKQLDD KRLAREAYME DMVEQVKSRL SEAGIEAEVY
GRPKHIYSIY KKMAQKNYEF DQLFDIRAMR IVVERLQDCY GALGIVHTNW RHLNKEFDDY
VATPKQNGYQ SIHTVVFGPE GKTVEIQIRT SDMHQDAELG VAAHWIYKEG ALPGRGSGYE
QKISWLRKLL QWQEEVVDGG DLAEELKNQV VEDRVYIFTP SGDIIDLPLG ATPLDFAYYI
HSNVGHRCIG AKVFGKIVPF THQLTTGDQV EILTQKQPNP SRDWLNPSLG YIKSSRARAK
IHHWFKQLDR DKNLSAGKDI LDNELQKLGL NYKDLAPAIK RFNFKELDDL MVAIGAGDVR
LNQMLNFVTD RTEDEPVIRF KNPTKVSGDK NGIVVDGVGS LMSHVAKCCR PVPGDAIIGY
ITQGRGIGVH KDDCDSFNNL KEQHPERVLS VSWSDDINGS YALSIKIEAT DRSGLIRDIS
SVLANEKVNV LNMNVNTVTD NQLAIFTMQI EVHDLSGTNR VLSKLHQIEG VHDAKRGH
//
