ID A0A1Q2HV38_9CORY Unreviewed; 775 AA.
AC A0A1Q2HV38;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN Name=uvrD2 {ECO:0000313|EMBL:AQQ14714.1};
GN ORFNames=CGLAU_03685 {ECO:0000313|EMBL:AQQ14714.1};
OS Corynebacterium glaucum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=187491 {ECO:0000313|EMBL:AQQ14714.1, ECO:0000313|Proteomes:UP000217209};
RN [1] {ECO:0000313|EMBL:AQQ14714.1, ECO:0000313|Proteomes:UP000217209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 30827 {ECO:0000313|EMBL:AQQ14714.1,
RC ECO:0000313|Proteomes:UP000217209};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; CP019688; AQQ14714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2HV38; -.
DR KEGG; cgv:CGLAU_03685; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000217209; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 2.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000217209}.
FT DOMAIN 9..295
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 296..602
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 775 AA; 85943 MW; 3CEF82121275CEBD CRC64;
MSNQTDLTLG LNPQQQAAVV HEGGPLLIVA GAGSGKTAVL TRRIAHLLQD RGVAPWQILA
ITFTNKAAAE MRERVAALVG QTAERMWVAT FHSVCVRILR QQAQLVPGLN TNFTIYDADD
SRRLLGMIAK DFNLDLKKFT PRTLANAISN LKNELIGPEQ ALPEAERTHN PFETTVAKVY
AEYQRRLRQS NALDFDDLIG EVVRIFKMHP QVTDYYRRRF RHVLVDEYQD TNHAQYELIH
TLVGDGPDAP ELAVVGDSDQ SIYAFRGATI RNIEEFERDY PNATTIVLEQ NYRSTQNILS
AANSVIAQNV DRRPKKLWTD HGSGEKIVGY VADNEHDEAR FIAAEIDALT DQGVRYSDIA
IMYRTNNASR AMEDIFIRSG IPYKVVGGTR FYERREIRDI VAYLKVLDNP DDTVSLRRIV
NVPKRAIGDK AQAMVALHAD NHGQSFGRSL IDASLGNVDM LNSRSTNAIS GFVQMMEGIR
EEMPQMVNEV TGMPDLGQLV ARILDATGYK SELEASNDPQ DAARLDNLNE LVSVAREFSS
EAANQLAYMT QEDLDAAMEE GEPAPGSLQA FLEKVSLVAD ADQLPDNDQG VVTMMTLHTA
KGLEFPVVFV TGWEDGQFPH LRSLGDPEEL AEERRLAYVG ITRARERLYL TRAILRASWG
APVTNPASRF LAEVPEDLVD WRRVAPEPEF NSSAWGTPAS VPARAKRTRR GIAGDMKVNK
NLELAVGDRV NHAKYGLGTV LTVEGTGVRE TVTVDFGSSG TVRLMLIGGV PMEKL
//
