ID A0A1Q2HYK3_9CORY Unreviewed; 1048 AA.
AC A0A1Q2HYK3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ribonuclease E {ECO:0000313|EMBL:AQQ15899.1};
DE EC=3.1.26.12 {ECO:0000313|EMBL:AQQ15899.1};
GN Name=rne {ECO:0000313|EMBL:AQQ15899.1};
GN ORFNames=CGLAU_09740 {ECO:0000313|EMBL:AQQ15899.1};
OS Corynebacterium glaucum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=187491 {ECO:0000313|EMBL:AQQ15899.1, ECO:0000313|Proteomes:UP000217209};
RN [1] {ECO:0000313|EMBL:AQQ15899.1, ECO:0000313|Proteomes:UP000217209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 30827 {ECO:0000313|EMBL:AQQ15899.1,
RC ECO:0000313|Proteomes:UP000217209};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CP019688; AQQ15899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2HYK3; -.
DR KEGG; cgv:CGLAU_09740; -.
DR Proteomes; UP000217209; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd04453; S1_RNase_E; 1.
DR Gene3D; 1.10.10.2480; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR006847; IF2_N.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR InterPro; IPR004659; RNase_E/G.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00757; RNaseEG; 1.
DR PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR PANTHER; PTHR30001:SF0; RIBONUCLEASE G; 1.
DR Pfam; PF04760; IF2_N; 1.
DR Pfam; PF10150; RNase_E_G; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AQQ15899.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000217209};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 416..499
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..198
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 114814 MW; F8372338696787AE CRC64;
MAHTQDSTEQ QQSDATKAPR KASRKAAKKT AKKTAKKASK KSVKKATKSS ALNESAATEN
TAPNPYADFD RTQLSDKMRV FQFAKALDLT SKDLILALAD LGVVKVAQSS LTRAEMEQLL
DALAAKGDSP EPEAAPAEEK IRERIRKDVA NEITQIERKV EAELTDREED RDEDDVTDAE
DDALTDPEDV DDAFDLLTDI EPEVTPAPVE ENPAYAPIFK APTRSKRRRA SRPSDAEAAD
AANASDGAAD ATDTADTADS AEVAGTANTV EAEAAAPAET RSRKRRRGSR KSSETKVDTS
DENANILDVE DTDDFVGARD VADVEELEEP KAIKGSSRLE AQRRRRTEKR EEQRKRSRIV
SQAEFLARRE SVTRTMVVRE RDRHDGPGRI TQVGVLEDGL LVEHFVTSDQ QASMIGNIYL
GRVQNVLPSM EAAFIDIGQG RNGVLYAGEV DWKAAGLGGR SRRIEHALKS GDQVVVQVTK
DPVGHKGARL TTQISLAGRF LVYVPGGRSA GISRKLPAPE RKRLKEVLNN VVPGKGGAII
RTAAEGVPED AIAADVNRLH TQWEAIQEHA EREKNSKGAK PVTLYEEPNL LIKVVRDLFN
EDFAALIVDG KKPWNTVKAY VESVAPDLAD RLEQFDRNDH GGKDAFEVYR VDEQIQKALS
RSVWLPSGGS LIIDRTEAMT VIDVNTGKFT GSGGSLEETV TSNNLEAAEE IVRQIRLRDI
GGIIIIDFID MILPENQDLV LRRLKEALGR DRTRHQVSEV TSLGLVQMTR KRLGTGLLET
FSEPCETCGG RGIVLAEDPV DHDAHDDHPR RGKDRDRRRP VGEHPAAKAM RTHSEEELDE
IAGSVIADQG DDAGNGAGGD GEERETKRSR RRGRRGGSRG RGKQREADST NVEATDAAED
EVSSDAAYAV EAAVAAAQVD STEPVKAAES AAQTYEEAVE EFESSPRRKR RTRGNSKSDY
RPKPEDFVQP AEVEVEESEA VEEGVDKQKP ATTRSGRDRR RASRRSTSTA SQPKKQEARE
GRVKAASKDS ATQSRAGRGR RRASRKSS
//
