ID A0A1Q2M7S2_9GAMM Unreviewed; 1032 AA.
AC A0A1Q2M7S2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=AAA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Mag101_14670 {ECO:0000313|EMBL:AQQ68736.1};
OS Microbulbifer agarilyticus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=260552 {ECO:0000313|EMBL:AQQ68736.1, ECO:0000313|Proteomes:UP000188219};
RN [1] {ECO:0000313|EMBL:AQQ68736.1, ECO:0000313|Proteomes:UP000188219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GP101 {ECO:0000313|EMBL:AQQ68736.1,
RC ECO:0000313|Proteomes:UP000188219};
RA Jung J., Bae S.S., Baek K.;
RT "Genome of Microbulbifer agarilyticus GP101.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP019650; AQQ68736.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2M7S2; -.
DR STRING; 260552.Mag101_14670; -.
DR KEGG; maga:Mag101_14670; -.
DR OrthoDB; 9775724at2; -.
DR Proteomes; UP000188219; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000188219};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 32..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..107
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 388..459
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 531..681
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT REGION 969..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 348..382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1006..1032
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 114734 MW; 055DFEB69453534D CRC64;
MNYAQGNGGD ELPQEQSLDL LRYWKILFAK RWLIFGLSVA MSAVAIAFIY KMPSRYQATA
SLVFEVDQAN PVSVEEIYDL GAQRRDYILT QTEMLKSRQL AERVIQRLNL VNHPEFAAQS
KSGLFGLFSK DSASDSSMSA KAETATLDNV TSAFLKRLTI SPARNTNLVK VQFEAKSAKL
SADVANALVE EFIFFQSEAK EQFTNRATSW LNERQETLRS KLEASEQNLQ NFRETEDLVD
LSGVRGLSEQ DLNAATTQLQ ETRREFKQIA SVFNQFERLK GNELALANLP EVISNPLIQE
IKRNEAAAER NVSELARRYK PKHPTMIAAS NELDMIRDQL ASEVRILADS IESQYNTAQA
RVAAQEQEVQ RAKAAYQNVS QKEFRYQELV REVEANRQLY DTFFTRANET REASGFEIAP
ARFLDSAVIP NTATKPNKKL LAMMAIALSA VFATAIALLL DFLRMGVRSP EDVEVHLGQN
LIGLLPQVST PKDSKLNLRT FFDPNHYTFS EAVRTLRTGV VLTGLGKSMR TILITSSVPA
EGKTTVAENL AFALSQVERV LLVDLDLRKP TVAADFRIAS NHPGITDLIQ GNKPLEECVY
KDIGSNLHVM PSGGHLTDPQ QLLVSPRFSE TISSLAQDYD RIVIDSPPVQ AVSDALIISH
LADALLYVIK YDSTNKRTVS RGIERLTKIN SKIDGIVLTH VDTSKDAIYA DEYYDYDYGN
SRRDRKPVAP TVASSQALGA VSSPRVHTDT VSTRIAAEPK SDTYAVSRSN IHTDHTPVHT
ANSETTVANE LVEDDVAVVA EPEYQMVAEP EVTTEVENAF VAMEAAVDVE EQHATEAEID
PAETVFVRAE DHVPDDLISD ADVVAGSDVS TDSEFTQESI QSAVEEAAHE AIHETIHEDI
QEAVQESIRE DSQEAYQGRL TQSSLDRIVE AEKATSYFSA PTSLEDDTAD ASIDRELLSD
VTPHEISQEI PQFEVEKLAE EDTSSEVDLE DGSTSVTDEK SKKKSRSPRS QRSRAKKKQR
KKRARAKRRA AK
//
