ID A0A1Q2YGL1_9ASCO Unreviewed; 319 AA.
AC A0A1Q2YGL1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Acetyl-coenzyme A synthetase 1 {ECO:0000256|ARBA:ARBA00040317};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE AltName: Full=Acetate--CoA ligase 1 {ECO:0000256|ARBA:ARBA00042759};
DE AltName: Full=Acyl-activating enzyme 1 {ECO:0000256|ARBA:ARBA00043000};
GN ORFNames=PMKS-002148 {ECO:0000313|EMBL:GAV28674.1};
OS Pichia membranifaciens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4926 {ECO:0000313|EMBL:GAV28674.1, ECO:0000313|Proteomes:UP000186136};
RN [1] {ECO:0000313|EMBL:GAV28674.1, ECO:0000313|Proteomes:UP000186136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KS47-1 {ECO:0000313|EMBL:GAV28674.1,
RC ECO:0000313|Proteomes:UP000186136};
RA Konishi M., Ishida M., Arakawa T., Kato Y., Horiuchi J.;
RT "Whole genome shotgun sequence of Pichia membranifaciens KS47-1.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV28674.1}.
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DR EMBL; BDGI01000077; GAV28674.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q2YGL1; -.
DR Proteomes; UP000186136; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186136}.
FT DOMAIN 1..45
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 47..154
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 200..278
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 319 AA; 34927 MW; 03F2331CC7BE121D CRC64;
MAQENLSWSK PFTVAKVPEA PHLRDNNGEP SAWFVDGELN ACYNCVDRWA IKNPNKPAII
YEADEPNEGR IITFGELLKD VCRFAQVLKK LGVKKGDTVA VYLPMIPEAI VALMAIVRIG
AVHSVVFAGF SSTSLKDRVL DADSKIVITT DESKRGGKII ETKKIVDDAL THCPDDGFYW
ILGRVDDVVN VSGHRLSTAE IEAALIEHPL VSENAVVGFP DELTGSAVAA FVSLKKEIDD
VAATKKELVL TVRKEIGPFA APKQIIIVDD LPKTRSGKIM RRILRKILAG EEDQLGDVST
LSNPNVVSHL IEVVHSMKK
//
