ID A0A1Q3E476_LENED Unreviewed; 423 AA.
AC A0A1Q3E476;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=DRMBL-domain-containing protein {ECO:0000313|EMBL:GAW02033.1};
GN ORFNames=LENED_003661 {ECO:0000313|EMBL:GAW02033.1};
OS Lentinula edodes (Shiitake mushroom) (Lentinus edodes).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Omphalotaceae; Lentinula.
OX NCBI_TaxID=5353 {ECO:0000313|EMBL:GAW02033.1, ECO:0000313|Proteomes:UP000188533};
RN [1] {ECO:0000313|EMBL:GAW02033.1, ECO:0000313|Proteomes:UP000188533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02033.1,
RC ECO:0000313|Proteomes:UP000188533};
RG Lentinula edodes genome sequencing consortium;
RA Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA Konno N.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAW02033.1, ECO:0000313|Proteomes:UP000188533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02033.1,
RC ECO:0000313|Proteomes:UP000188533};
RA Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA Konno N.;
RT "A genome survey and senescence transcriptome analysis in Lentinula
RT edodes.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW02033.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BDGU01000080; GAW02033.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q3E476; -.
DR STRING; 5353.A0A1Q3E476; -.
DR Proteomes; UP000188533; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 12..180
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 261..387
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 423 AA; 47513 MW; CBADEC8B14CCB673 CRC64;
MPIAVDAFKY GTIPSVTAYF LTHAHSDHYT ALSNTWNSGP IYCSEGTANL IKHMLRVHPS
WVHPLPMNVP TEIPNTGGVR VTLIEANHCP GSCLFFFEGK QTVDAGDSTF KSPYVGTTRT
FRFLHCGDFR ASPAHIEHPE VKGKRIDHVY LDTTYLDPKY TFPPQPLVIS ACAELAKRIQ
HGDSLLYPAQ PGTMSAWVTT TSNADVKGKQ KDTAKANNVL MIVGTYSIGK ERIVKAIARA
LQSKIYCDSR KTAILRCQAD PELESLLTKN PLDAQVHIVP LGHVNLDKLK EYSEKYKNHF
KKVVGFRPTG WTYVQPAGTD QVPSIPTIIS RAQRNTFTYT DLRQGRGSSS TLQVYPVPYS
EHSSFFELTC FAMSFEWGKM IATVNVGSEA SRGKMAKWVE RWEKERKKQG KNYIVPSRKD
DYW
//
