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Database: UniProt
Entry: A0A1Q3E543_LENED
LinkDB: A0A1Q3E543_LENED
Original site: A0A1Q3E543_LENED 
ID   A0A1Q3E543_LENED        Unreviewed;      1067 AA.
AC   A0A1Q3E543;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-DEC-2018, entry version 12.
DE   SubName: Full=Tyrosinase {ECO:0000313|EMBL:GAW02360.1};
GN   ORFNames=LENED_004013 {ECO:0000313|EMBL:GAW02360.1};
OS   Lentinula edodes (Shiitake mushroom) (Lentinus edodes).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Omphalotaceae;
OC   Lentinula.
OX   NCBI_TaxID=5353 {ECO:0000313|EMBL:GAW02360.1, ECO:0000313|Proteomes:UP000188533};
RN   [1] {ECO:0000313|EMBL:GAW02360.1, ECO:0000313|Proteomes:UP000188533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02360.1,
RC   ECO:0000313|Proteomes:UP000188533};
RG   Lentinula edodes genome sequencing consortium;
RA   Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA   Konno N.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAW02360.1, ECO:0000313|Proteomes:UP000188533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02360.1,
RC   ECO:0000313|Proteomes:UP000188533};
RA   Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA   Konno N.;
RT   "A genome survey and senescence transcriptome analysis in Lentinula
RT   edodes.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAW02360.1}.
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DR   EMBL; BDGU01000093; GAW02360.1; -; Genomic_DNA.
DR   Proteomes; UP000188533; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   Gene3D; 1.10.4160.10; -; 1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   InterPro; IPR038271; Pur-cyt_permease_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   InterPro; IPR008922; Unchr_di-copper_centre.
DR   PANTHER; PTHR31806; PTHR31806; 2.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000188533};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00067573};
KW   Reference proteome {ECO:0000313|Proteomes:UP000188533};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    657    680       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    687    706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    726    746       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    767    786       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    792    813       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    844    863       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    893    918       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    930    952       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    958    979       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    999   1017       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1056       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       90    107       Tyrosinase_Cu-bd. {ECO:0000259|PROSITE:
FT                                PS00497}.
FT   DOMAIN      283    294       Tyrosinase_Cu-bd. {ECO:0000259|PROSITE:
FT                                PS00498}.
SQ   SEQUENCE   1067 AA;  117977 MW;  D709623F43F1EED1 CRC64;
     MSHYLVTGAT GGSTSGATAP NRLEINDFVK QEDQFSLYIQ ALQYIYSSKS QDDIDSFFQI
     GGIHGLPYVP WDGAGNKPVD TDAWEGYCTH GSVLFPTFHR PYVLLIEQAI QAAAVDIAAT
     YIVDRARYQD AALNLRQPYW DWARNPVPPP EVISLDEVTI VNPSGEKISV PNPLRRYTFH
     PIDPSFPEPY QSWSTTLRHP LSDDANASDN VPELKATLRS AGPQLKTKTY NLLTRVHTWP
     AFSNHTPDDG GSTSNSLEGI HDSVHVDVGG NGQMSDPSVA GFDPIFFMHH AQVDRLLSLW
     SALNPRVWIT DGPSGDGTWT IPPDTVVGKD TDLTPFWNTQ SSYWISANVT DTRFHDWQCH
     KRCLFAPVKI ASTVRNNEQK EFWEWTARVQ VKKYEIGGSF KVLFFLGSVP SDPKEWATDP
     HFVGAFHGFV NSSAERCANC RRQQDVVLEG FVHLNEGIAN ISNLNSFDPI VVEPYLKENF
     HWRVQKVSGE VVNLDAATSL EVVVVATRLE LPPGEIFPRL KTDRWYTMHV FNTQLTPSAA
     LLFAIKESVT AILNRKENHA RRECNYCSGC KKQAHATKFP TMNDKILEDT NDPGLPTTIV
     PHTADFDGSS FGDRSSRSKL GGWKGLSRHA LRWGIETHGI APTSEEERTD TRMWQMFTVW
     FSAILNLTGM STGALGPIFF SLDFRECIIV LVVADIICCL VPAYFVVFGP KLGTRTMVQS
     RFSFGYYGAM LISTLNVFSQ IGWLIINSIV GGQVLAAVST KLNDTTGIVI IVLISFVLSF
     CGYKTLHWYE TYIWLPSVVL FIALLGVGGN QLVAQIPILI SSTPAAAAVD HTHVEDFLLG
     LCRYLHLCSH IIGAAFASAA PAIPSWETGL GDGEDFGRFL VAILEPIGNF GKFLVVLGAL
     TVTAPCAITM YSFGVSLMSI SPMFAKVPRY IYSLICTAIV IPIAIVGATH FFTAFEDVLN
     LIGYWATSYA SIVLCEHFLF RKNDFARYSV VDWNTSSNLP LGVAAILAFL CSFAVIVPSM
     NQPWYTGPIA NAGTGDIGLI TGFFASGLLY MVFRAVEVKF SARRRNG
//
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