ID A0A1Q3E5C7_LENED Unreviewed; 2138 AA.
AC A0A1Q3E5C7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=LENED_004106 {ECO:0000313|EMBL:GAW02450.1};
OS Lentinula edodes (Shiitake mushroom) (Lentinus edodes).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Omphalotaceae; Lentinula.
OX NCBI_TaxID=5353 {ECO:0000313|EMBL:GAW02450.1, ECO:0000313|Proteomes:UP000188533};
RN [1] {ECO:0000313|EMBL:GAW02450.1, ECO:0000313|Proteomes:UP000188533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02450.1,
RC ECO:0000313|Proteomes:UP000188533};
RG Lentinula edodes genome sequencing consortium;
RA Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA Konno N.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAW02450.1, ECO:0000313|Proteomes:UP000188533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 111202 {ECO:0000313|EMBL:GAW02450.1,
RC ECO:0000313|Proteomes:UP000188533};
RA Sakamoto Y., Nakade K., Sato S., Yoshida Y., Miyazaki K., Natsume S.,
RA Konno N.;
RT "A genome survey and senescence transcriptome analysis in Lentinula
RT edodes.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW02450.1}.
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DR EMBL; BDGU01000096; GAW02450.1; -; Genomic_DNA.
DR STRING; 5353.A0A1Q3E5C7; -.
DR Proteomes; UP000188533; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF124; SERINE_THREONINE-PROTEIN KINASE MEC1; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:GAW02450.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1110..1665
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1774..2085
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2106..2138
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2054..2073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2138 AA; 240464 MW; E47B8C8E1E895CFB CRC64;
MWKIMRSIIE ELLSLSHDII NSNLPLAFPF DASPFRRPRL QPIDPDASQE RVMMIISSQA
DIPRFLSLII DITTNALYPN TLCGWFLFDL EQKVIENVQQ TFDYCLSVPS AARFKGCTMI
LSALPFEVLK CKDRISPLMN LPFRLLRRRL LAGPSTAWDV VDQFFLEAKN LPILVKAELV
EILGFARGER FEGHQAVVMA YIEACFSQMD IDSLNTLSKV IAGTEFRGEV CARISEVIRK
RFAVLEVETV VKGPLPASPW RGTLSTIVQD LAQPEEVDWM EDDDDQRYVQ YALDDIVSLY
KTRHPPTHES RTSVLESATH LCDLLRTRGS LKWSTTPLCF VLSTWLLQGP NVPTDTKRKV
FVMVAGLLKL HTMNGSPDET LYPLARLIYR NLLDSNASVR LNVGKALGAL VALYGERNTD
VWERTDACFA QFYGIMEGGK LTVKETAVLV VGGMAKDPTL HSDIIGQALC FLVAQLGRTN
PVLKGSAYMQ IVAAAKSQKK TSAYPLLLPY MDKIAPFLVT RMCSQPTMIS ETCRLMCISV
TDFLRTTLGK TLPTLFANRE QAVLDAMDKE LSQTPTSMFL HNSHGILAHV YRLDQGTHSA
LDFITRMLSS ATVASNGKRT TVDAQSITKS CVIPLLAELV TSLGDHNELV AQNAIDALRK
VDKVLNGSDR GDLGAFLKNY MLGLISHIND MLQDVQGKKS VDAKKKILKS LGVLMTQIGA
ATASIAPQIM ATFQTMVGFP ELCEETLYSW HQFITMLNAE ELAPHVGSTS AAFVTSWSAF
TLPARSLAKK TLKYIILDKG SELIDNGLDD LVDMSAIPEL RDIYEHILNL RGELTPVSRL
SSILERASTH NHAMALQSLH ELKQFMLIDH RDLIRELASG DVFDPLVGQV LAVLLTAAGH
DVDESDPLRS LAFECLAILG AVDPDRCELR VKESSMIVYQ NFEDDEESIA FALHLITDLL
VEAFRSTSDM RYQSHLAFTI QELLRFCNFT PALITPSRQS VAVKVRRTAQ KIFGVFPSVI
RNKDVAVAHR LLPHLVLNVL LSGSEEGTTE IRLEILAVLE DQVNLGSTSS SDKKILSAQA
VFMLLDHLNR WLRKIRQEVT KESNPRQVSE AQENLVKCKA YALSLMNFES RIVELQQRSS
NHHDLPTYYE HLHEIYAHLD EPDGMEGVST MILSPSLEHQ IRHHESSGHW TSAQSCWEVR
LQQFPDNVDY HLGLLRCLRN LGHYDTLRTH VRGVLTRNPD WQPALASFQI ESAWMVGAWE
DVQNIVDSTD VATAQIAIAR LLLALRSRDS AAITTALDGA RMVLGGPIAA AGVNNYRRSY
EAMLDLHLTH ELETIYNAIS SLSEQSTSVN SALMRLSEIL SSRLDSTLPT FRTRESVLSM
RRTAFALINI PGSQVLRKEI GRSWLASAKI ARKAGQWQTA YSAMLQSQQN KTRYSFMESA
KLVKAMGDPL HALQQLENSM QLHNLLEDEV NVVDLTNDDN EENLKKMKAK VRLVRARWMN
ESERFDARMV LKTFTNVAIL MPNWESGQYY LGQFQDECYK NLPIAERSSR GLKMNLSTIR
AYAEAINLGT KYIYQTVPRL LTLWLDLGED AKVAETDTFR LINQAVSGAI KNSPIYKWFT
AFPQIVSRIG HSNPEVYKQL ARLIAKVIQS YPNQALWLFA AVIKSKKRER SQRGSLILER
IRNNPSLAQS SVPKLVSQSL DMTNELLELC NFHTPNIERK KLTMTRDFPR LAKLGKSNLI
IPLQESLTAS LPPVSCSESV HQPFPSNAPT FAGFAEEIEI MHSLAKPRKI TIHGSDGQTY
MFLGKPKDDL RKDARLMDFN AIINKLLKAN SESRRRQLHI RTYGVVTLNE ECGFIQWVPH
TRPVRPIIVN LYNNRHIPGW CAEMADVFTR IKGTNDGNKA ADLFTKKILS LFPPVFHEWF
IETFPEPTAW LASRLTYART TAVMSMVGFI LGLGDRHCEN ILLDENTGDL IHVDFNCLFE
KGKTFETPER VPFRLTQNLV DALGVTGVEG VFRTACEVTM QLLRDNKDSL MSVLDAFVHD
PLVEWEEEKM KLDRKQQHAN ATDAQRKNAV KPATDLRSLA KNSLKGIEKK LRGHYRPTPE
KHAYEKEVST SNLVQLLIQE ATDIANLARM YPGWASWH
//