ID A0A1Q3GSP1_9BACT Unreviewed; 759 AA.
AC A0A1Q3GSP1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=BKI52_19985 {ECO:0000313|EMBL:OJJ19098.1};
OS marine bacterium AO1-C.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae.
OX NCBI_TaxID=1905359 {ECO:0000313|EMBL:OJJ19098.1, ECO:0000313|Proteomes:UP000186474};
RN [1] {ECO:0000313|EMBL:OJJ19098.1, ECO:0000313|Proteomes:UP000186474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AO1-C {ECO:0000313|EMBL:OJJ19098.1};
RA Buerger P., Wood-Charlson E.M., Weynberg K.D., Willis B., Van Oppen M.J.;
RT "CRISPR-Cas defence system in Roseofilum reptotaenium: evidence of a
RT bacteriophage-cyanobacterium arms race in the coral black band disease.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJJ19098.1}.
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DR EMBL; MLAY01000007; OJJ19098.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q3GSP1; -.
DR STRING; 1905359.BKI52_19985; -.
DR Proteomes; UP000186474; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186474};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 32..65
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 152..185
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 581..712
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 158..188
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 318..476
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 505..546
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 759 AA; 87071 MW; A0B8EF7E2A0D4B23 CRC64;
MGGLVCHAQY QAKDLEKLIK QLNQASSNSE KAETLYKIGL WYEHDKGYEK AIQYLDQAYQ
LEEKEGNQTG QVNNLQHMVY AYKQTGLYPD AIEHSKDLLK LHQKQGNQTG YNNTLKDISM
LHKLNHDYKS AIKTDQELVS IYKENNDQKA LVKTYADLGF LNLELDNASQ ALKEYDNAQK
INQNIEGQTS LQGDLLINMG FIFGRELKIQ DKAKEYYQKA LALKQQTNDY GTQAMLHNEI
GQIDYKNGQK KEAQQHAQKA IALAKNHPGD QKYNTLAKSY QLLADLHAKD NDHKTSAQYY
AQYLEVQNVL DSLENERLVT QQQQLRKMQA ENKKTRSRLF AKERRRSRMQ DQLLKQENEL
KALKIKEKEA DIIRKQQLLQ QEQLKTAELE KDKVVQLLAL AEQKQKTAEQ SALAEKQRML
AEKQKLENEK KQEELERAKQ EKIAIEKEKE LQKTKLDAAK KAEKLKEQEL QHVKERNRLR
DYLFVLFAVV VVLVIMGLIS TVRSRKKLQV KNTLLNEANN EINEQKEEIL VQNEELNTRN
QQIETERVKS DNLLLNILPF ETAQELKDKG SATPQHYEQV SVLFTDFKGF TKLAEKLSPE
DVIAELNHCF TAFDDICKKH NIEKIKTIGD AYMAAGGVPV ANTSNAIDAI NAGLEMQTFM
AQWKAQKLAQ NLPVWELRLG IHTGEIVAGV VGKDKFAYDI WGDTVNLASR MESSGEPGMV
NISGDTYELV KDHFKTEYRG KIKAKNKGEV DMYFIKGTA
//
