ID A0A1Q3Q2E3_9BACT Unreviewed; 1023 AA.
AC A0A1Q3Q2E3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BGO32_01925 {ECO:0000313|EMBL:OJV27937.1};
OS Bacteroidetes bacterium 37-13.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1895921 {ECO:0000313|EMBL:OJV27937.1, ECO:0000313|Proteomes:UP000185627};
RN [1] {ECO:0000313|EMBL:OJV27937.1, ECO:0000313|Proteomes:UP000185627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=37-13 {ECO:0000313|EMBL:OJV27937.1};
RA Kantor R.S., Huddy R.J., Iyer R., Thomas B.C., Brown C.T., Anantharaman K.,
RA Tringe S., Hettich R.L., Harrison S.T., Banfield J.F.;
RT "Genome-resolved meta-omics ties microbial dynamics to process performance
RT in biotechnology for thiocyanate degradation.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJV27937.1}.
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DR EMBL; MKTC01000017; OJV27937.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q3Q2E3; -.
DR STRING; 1895921.BGO32_01925; -.
DR Proteomes; UP000185627; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:OJV27937.1};
KW Hydrolase {ECO:0000313|EMBL:OJV27937.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:OJV27937.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 310..563
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 1023 AA; 119006 MW; BF4370302430E39B CRC64;
MTGQEVIELI GLDRAKSVNP KGKKLLESES IVFDQIREFG VDSIYFNTDE KGNSFPAVFL
KEVKTFDLPT LQNITDIHKK IWNYKKVLFL YVYSETEIRI YNCSETPLIK TQENFDYAKE
LQNIEIKSYQ YSDKEQLEEL NRLFSRIAID SGIIWTLEDA QFVRDKIKLQ RRVDKYLVES
LVNTANQLER QGLEINFIHK IILRSLFLLY LEHRGATDEK FYGQIKKGTK SYFDILNDVK
ATYDLYEKLE EYFNGNVFTL EKDKNNQITE KISVEQLQLI QKCFVSGNDN TLQAKLFDDW
RLFDFSIIQI ELLSEIYENF LFKTDPELKK KTGTYYTPPA LVEFILNEKL PTNNGEQNYN
VKVLDPSCGS GIFLVESFNR LVKRYENQYK AKPDFATLVK LLEENIFGIE INPQAIKVAA
FSLYLALVDK LDPKNLWQKK KHRLPNLINN PDDSSLKAQG KNLFCRDTIL QNVEIENIEF
NLVVGNPPFG KTDLLESVRN YCDKYGFAKE MVLPFLHKAT KFAPNGEIAL IFNTKILTNT
EDVYKDFRKW LFNDCYVEKV FNFSILRNTK KNFGGQLFGD ATGPISIVFY QKELPKIPFD
KIAYYAPKTF VKTDVIDGLN IDFTDLKYLP REECQKSDTK IWKISMWGHS LDFELYKLIS
NSFDTLSTVF ERNPNKWIKG TGLLKASAEN LDKGKAQKVN EKIIDTKKIL RFYTNSTSLY
TTDKLFNPKD FKKFTPPFLL VKEGQQNWMY CATIVDYNAF FLKSAFGIKS VENDAYNKVI
AALINSTFAK YYLSLISSSW GIERERIQPN EILLLPYLTE EKNIHKLTVI SSLVDKIIED
EKAGKTNGIP NIEKEINEQI FNLLNVDDRQ KSLINDTITY NLDLLENKEK SKALCPILKE
QTTEYGATIS AELNEFLDGQ DLFANTTVFE SINRNSPLMM IKLSFAKKQK EVIKSKEFID
DELKKIDQHL WEEKSSNIYF RKKLNYKKGD DIYIIRPNQR RFWSKSMAIE DASELILEIL
NGN
//
