ID A0A1Q4H8A4_9MYCO Unreviewed; 648 AA.
AC A0A1Q4H8A4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:OJZ63768.1};
DE EC=1.3.5.1 {ECO:0000313|EMBL:PEG54258.1};
GN Name=sdhA {ECO:0000313|EMBL:OJZ63768.1};
GN ORFNames=BRW64_20490 {ECO:0000313|EMBL:OJZ63768.1}, BV510_03605
GN {ECO:0000313|EMBL:OPE55736.1}, CRI78_11665
GN {ECO:0000313|EMBL:PEG54258.1};
OS Mycolicibacterium diernhoferi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1801 {ECO:0000313|EMBL:OJZ63768.1, ECO:0000313|Proteomes:UP000186837};
RN [1] {ECO:0000313|EMBL:OPE55736.1, ECO:0000313|Proteomes:UP000191039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BM1 {ECO:0000313|EMBL:OPE55736.1,
RC ECO:0000313|Proteomes:UP000191039};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RT "genome sequences of unsequenced Mycobacteria.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OJZ63768.1, ECO:0000313|Proteomes:UP000186837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bard {ECO:0000313|EMBL:OJZ63768.1,
RC ECO:0000313|Proteomes:UP000186837};
RA Greninger A.L., Fang F., Jerome K.R.;
RT "Genome sequences of unsequenced Mycobacteria.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PEG54258.1, ECO:0000313|Proteomes:UP000220340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP141170001 {ECO:0000313|EMBL:PEG54258.1,
RC ECO:0000313|Proteomes:UP000220340};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJZ63768.1}.
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DR EMBL; MPNS01000013; OJZ63768.1; -; Genomic_DNA.
DR EMBL; MIJD01000020; OPE55736.1; -; Genomic_DNA.
DR EMBL; PDCR01000013; PEG54258.1; -; Genomic_DNA.
DR RefSeq; WP_073858292.1; NZ_PDCR01000013.1.
DR AlphaFoldDB; A0A1Q4H8A4; -.
DR STRING; 1801.BRW64_20490; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000186837; Unassembled WGS sequence.
DR Proteomes; UP000191039; Unassembled WGS sequence.
DR Proteomes; UP000220340; Unassembled WGS sequence.
DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:PEG54258.1}.
FT DOMAIN 47..452
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 514..647
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT ACT_SITE 341
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 648 AA; 70252 MW; 6D8144332DFEBB20 CRC64;
MTAPGSLRVV GGPVDGGVPA GDPATAWERR LLDYRLVSPL NRGKFTVIVV GTGLAGAGCA
AALAELGYRV ESFTFHDTPR RAHSVAAQGG INAARGRKVD NDSVRRFVKD TVKGGDFRAR
EADCFRLAQE SARVIDHMNA IGAPFAREYG GSLATRSFGG VQVSRTYYTR GQTGQQLQIA
ATQALLRQVD AGAVNLHTRC EMLDLIVEDG VARGIVTRNL ITGEVRAFTG HAVVLATGGY
GNVFFRSTLA KNSNASATWR AHLRGALFAS PSFIQFHPTA LPVNSQWQSK TILMSESLRN
DGRIWVPKKS GDDRPANDIP EAERDYYLER MYPAYGNLAP RDVSSRAARA QIEAGHGVGP
LKNSVYLDFR DALRKLGRDK IAERYGNLFS MYSDATGEDP YQVPMRIAPG AHFAMGGLWS
DFDEMTSIPG LFVAGEAGWT YHGANRLGAN SLLSACVDGW FTLPYAIPNY LAGLLGTTAP
GSDQPAVRAT LADVERRVDA LLSIDGTQGP DRFHRRLGEI LYRGCGVSRS ESGLKAAIVD
IDALTADFWA DLRVAGTGAQ FNQELEKAGR VADFLGLARL MCVDALDRDE SCGAHFRVEH
QTSGGEAQRD DRHWCFVSAW EHNGDGPPVR RDEPLAFSAV PLQTRNYA
//
