ID A0A1Q4HJF3_9MYCO Unreviewed; 310 AA.
AC A0A1Q4HJF3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:OJZ67592.1};
GN ORFNames=BRW64_04835 {ECO:0000313|EMBL:OJZ67592.1}, BV510_05300
GN {ECO:0000313|EMBL:OPE55405.1}, CRI78_04405
GN {ECO:0000313|EMBL:PEG55861.1};
OS Mycolicibacterium diernhoferi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1801 {ECO:0000313|EMBL:OJZ67592.1, ECO:0000313|Proteomes:UP000186837};
RN [1] {ECO:0000313|EMBL:OPE55405.1, ECO:0000313|Proteomes:UP000191039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BM1 {ECO:0000313|EMBL:OPE55405.1,
RC ECO:0000313|Proteomes:UP000191039};
RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.;
RT "genome sequences of unsequenced Mycobacteria.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OJZ67592.1, ECO:0000313|Proteomes:UP000186837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bard {ECO:0000313|EMBL:OJZ67592.1,
RC ECO:0000313|Proteomes:UP000186837};
RA Greninger A.L., Fang F., Jerome K.R.;
RT "Genome sequences of unsequenced Mycobacteria.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PEG55861.1, ECO:0000313|Proteomes:UP000220340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP141170001 {ECO:0000313|EMBL:PEG55861.1,
RC ECO:0000313|Proteomes:UP000220340};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJZ67592.1}.
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DR EMBL; MPNS01000002; OJZ67592.1; -; Genomic_DNA.
DR EMBL; MIJD01000033; OPE55405.1; -; Genomic_DNA.
DR EMBL; PDCR01000004; PEG55861.1; -; Genomic_DNA.
DR RefSeq; WP_073854849.1; NZ_PDCR01000004.1.
DR AlphaFoldDB; A0A1Q4HJF3; -.
DR STRING; 1801.BRW64_04835; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000186837; Unassembled WGS sequence.
DR Proteomes; UP000191039; Unassembled WGS sequence.
DR Proteomes; UP000220340; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:OJZ67592.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..233
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 310 AA; 33368 MW; 4D5A5288EE2F8D7D CRC64;
MIELNNVAKT FGGSVPALRD VSFSVPTGSV CALLGHNGAG KTTTVKILST LLTPSSGTAV
VAGYDVAREP AKVRQNIGVT GQDAALDPRL TGRENLVLFG RLRGLRRAEA RARADELIDQ
FDMSHAADRQ VVGYSGGMRR RIDIAVSLVI LPKVLFLDEP TTGLDPRSRR DVWNLVSSLK
AQDITVLLTT QYLEEADILS DSIVILNAGQ IVAKGTADEL KRQTGSSYCE MTPLNPDDLP
RIAAALSDFD EVEVDTDANT VSVPAPSGVA TLTEVFRRMD EIGVELIDIS LRRPSLDEVF
LHLTSPVTTT
//
