ID A0A1Q4HKX4_9MYCO Unreviewed; 3075 AA.
AC A0A1Q4HKX4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:OJZ68167.1};
GN ORFNames=BRW64_00800 {ECO:0000313|EMBL:OJZ68167.1};
OS Mycolicibacterium diernhoferi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1801 {ECO:0000313|EMBL:OJZ68167.1, ECO:0000313|Proteomes:UP000186837};
RN [1] {ECO:0000313|EMBL:OJZ68167.1, ECO:0000313|Proteomes:UP000186837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bard {ECO:0000313|EMBL:OJZ68167.1,
RC ECO:0000313|Proteomes:UP000186837};
RA Greninger A.L., Fang F., Jerome K.R.;
RT "Genome sequences of unsequenced Mycobacteria.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJZ68167.1}.
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DR EMBL; MPNS01000001; OJZ68167.1; -; Genomic_DNA.
DR RefSeq; WP_073853287.1; NZ_MPNS01000001.1.
DR STRING; 1801.BRW64_00800; -.
DR Proteomes; UP000186837; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd03447; FAS_MaoC; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2541..2996
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1733..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2405..2430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3040..3060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3041..3060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3075 AA; 326244 MW; 9FC2811B5DCDB593 CRC64;
MTINEHDRVT AKNSLNEGSL SGANALVDLL NAGEPYAVAF GGQGGAWLES LEELVSSAGI
ESELSELVGE AALLLEPVAR ELVVVRPIGF EPLQWVRALA AEEPLPDTQQ LTTAAISGPG
ILLTQMAAIR ALTRQGLDLM GTPPVAMAGH SQGILGVESL KAKGTRDAEL LALLQLIGAA
GSLVSRRRGM VGRGDKTPMV SVTNVDPARI AELLEEFSTD VRTVLPPVLS IRNGRRSVVI
TGTPEQLGRF ELYCSKITEK EEAERKNKLR GGAVFSPVFN PVQVEVGFHT PRLADGVALV
DRWAAQCGID AELAHTMTES IFVNPIDWVA DVEALYNAGA RWIIDLGPSD TVTRLTAPVI
RGLGIGIVPA ATRAGQRSLF TVGAVPEVPA AWASYAPSTV TLPDGSVKLS TKFTRLTGRS
PILLAGMTPT TVDAKIVAAA ANAGHWAELA GGGQVTEKIF EDRVAELTQL LEPGRAIQFN
SLFLDPYLWK LQLGGKRIVQ KARQSGAPID GVIVTAGIPE LDEAVALIEE LNEIGIAHVV
FKPGTVDQIK AVIKIAAEVP DKDVIAHIEG GRAGGHHSWE DLDDLLLSTY ADLRKLSNIT
ICVGGGIGTP ERAAEYLAGR WSEQYGFPLM PVDGILVGTA AMATLEATTS PAVKQLLVDT
TGTDQWVGAG KAQGGMASGR SQLGADIHEI DNTASRCGRL LDEVAGDADA VAERRDEIIA
AMADTAKPYF GDVADMTYLQ WLDRYVELAI GDGDSTADTK ADGSPWLDVT WRDRFAEMLK
RAEARLHPSD SGPIETLFPA TPEGEALLEH PAAAVDILLN RYPDAEDIKL HPADVPFFTT
LCKTPGKPVN FVPVIDKDVR RWWRSDSLWQ AHDARYTADQ VCVIPGTAAV AGITRVDEPV
GELLDRFEQA AIDEVVASGA TPVPVVSRRQ ADPAVTGPIG VVLDSPDVLW AGRTAINPVH
RIGAPGEWQV NENRSAVHPS TGSRLELTDA GVTLSVPLSD IWIEIKLTLP AATVNGGMPV
VTTEDAAAAM RAVLAIAAGV DGVDSLPAVV DNTATVTVGW DPEEVADHTG VTATFGAPLA
PGLTLVPDAL VGKCWPAVFA TIGSAVTDAG FPVIEGLLSL VHLDHAAHLL TPMPKSVAEL
TVTATASDAT DTEVGRVVPV SVVISDAEGT ELARLEERFA IRGRTGAVEL EDPVRAGGAM
TDNATDTPRR RRRDVTMTAP TDMSAFAVVS GDHNPIHTDR AAALLAGLKG PIVHGMWLSA
AAQHVVTATD GRATPPARLV GWTSRFLGMV LPGDEIEFRV DRVGIDRGAE IVEVTAKVGG
DLVMAASAQL AAPKTVYAFP GQGIQHKGMG MEVRARSKAA RKVWDIADKF TRDTLGFSVL
HVVKDNPTSL IASGVHYHHP EGVLYLTQFT QVAMATVAAA QVAEMREQGA FVEGAIACGH
SVGEYTALAC VSGVYELPAL LEVVFHRGSK MHDIVPRDEK GRSNYRLAAI RPSQIDLPDD
DVTAFVAEIA ERTGEFLQIV NFNLRGSQYA IAGTVRGLEA LEEEIERRRE ISGGKRSFIL
VPGIDVPFHS EVLRVGVADF RRSLERVMPT DADPELLIGK YIPNLVPRPF TLDRDFIQEI
RDLVPAEPLD EVLADYDTWR NERPRELMRK IVIELLAWQF ASPVRWIETQ DLLFIEEAAG
GLGVERFVEI GVKTAPTVAG LATNTLKLPE YSHNTTEVLN AERDAAVLFA TDTDPEPEPE
EVSAPEASTE AAPAAAAPAA APAPAAAPSG GPRPDDIGFD AADATLVLIA LASKMRIDQI
EPLDSIESIT DGASSRRNQM LVDLGSELNL GAIDGAAEAD LSGLKAQVTK LARTYKPFGP
VLSDSINDQL RTVFGPSGKR PAYIAERVSK TWELGPGWAK HVTAEVALGT REGSSVRGGS
MGGLHDGALA DAASVDKVID GAVAAVAARK GIAVSLPSSG AAGGGVVDSA ALGEFAEKVT
GPNGVLANAA RTILGQLGLD NPVSAPEAVS DAELIDLVTT ELGSDWPRLV SPVFDARKAV
VFDDRWASAR EDLARIWLLD ESEIDTDWER LSQSFEGAGN VVGTQATWWQ GKALAAGRNV
HAALYGRAAA GAENPDKGGY ANEVAVVTGA SKGSIAASVV AQLLEGGATV VATTSRLDDD
RLAFYRTLYR DHARFNATLW VVPANMASYA DIDALVEWVG NEQTENLGPK AIHLKDAQNP
TLLFPFAAPR VAGDLSDAGA RSEMEMKVLL WAVQRLIAGL SHLGAERDIA SRLHVVLPGS
PNRGMFGGDG AYGEAKAALD AVVSRWKAET SWSQRVSLAH ALIGWTKGTG LMGHNDAIVG
AVEEAGLTTY TTAEMASMLL SLCNIESKVA AARAPIEVDF TGGLGEIEID MAELAAKARE
DMSAVADDES DEDESGIIRA LPSPPRGYAS APPPAWDDLD IDPADMVVIV GGAELGPYGS
SRTRFEMEVS GELSAAGVLE LAWTTGLVKW EDDPKPGWYD TETGDLVDEA ELVERYHDAV
VAKVGIREWV EDGFLDADHS APLLVSVFLD KDFTFVVSSE ADAREFVKYD PEHTVIAPVP
DSADWQVTRK AGTEIRVPRK VKLSRTVGGQ IPTGFDPQVY GVTPDMASSI DRLALWNLVA
TVDAFLSAGF SPAELMRWVH PSLVASTQGT GMGGMTSMQT MYHGNLLGRN KPNDILQEVL
PNVYAGHVVQ SYIGSYGSMI HPVAACATAA VSVEEGVDKI QLGKADFVVA GGYDDLTLEA
ITGFGDMSAT ADTEAMRAKG ISDAKFSRAN DRRRLGFVES QGGGTILLTR GDLAVQMGLP
VLAVVAYASS FGDGVHTSIP APGLGALGAG RGGRESRLAR SLAKLGVTAD DIAVISKHDT
STLANDPNET ELHERLAASM GRSKGAPLFV VSQKSLTGHA KGGAAAFQMM GLCQILRDGV
IPPNRSLDCV DDELSHAQHF VWVREALNLG EKFPLKAGLV TSLGFGHVSG LVALVHPQAL
IAALPADQRA DYQARANARV LDGQRRLASA IAGGPALYEK PADRRFGDET PEKRQEAAML
LDPDARLGAD EYYSK
//
