ID A0A1Q4UP57_9PROT Unreviewed; 345 AA.
AC A0A1Q4UP57;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:OKH87404.1};
GN ORFNames=LF95_11340 {ECO:0000313|EMBL:OKH87404.1};
OS Thalassospira sp. TSL5-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Thalassospiraceae; Thalassospira.
OX NCBI_TaxID=1544451 {ECO:0000313|EMBL:OKH87404.1, ECO:0000313|Proteomes:UP000186302};
RN [1] {ECO:0000313|EMBL:OKH87404.1, ECO:0000313|Proteomes:UP000186302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSL5-1 {ECO:0000313|EMBL:OKH87404.1,
RC ECO:0000313|Proteomes:UP000186302};
RA Zhou H., Wang H.;
RT "Genome sequencing of Thalassospira sp. TSL5-1.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH87404.1}.
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DR EMBL; JRJD01000003; OKH87404.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4UP57; -.
DR STRING; 1544451.LF95_11340; -.
DR Proteomes; UP000186302; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 107..330
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 345 AA; 37182 MW; C66C89DF5E95B221 CRC64;
MLGDLNERSR EVFRQIVDAY VETGEPIGSR TIARRLSEKL SAATVRNVMA DLEDQGLLVA
PHISAGRLPS EKGLRLFVNA LMEVGDLPNA ERDQLTKNCE RAGYSLDEML GEATSMLSGL
SRCAGLVVAP KTDGLRLKQI EFVPLSPGKV LAVLVAQNGS VENRIVDVPT NMPTSALTEA
ANYLNTQLAG KTLDDARLLV ARERERIQTE LDVLSASLID AGIATWAGGV KDSSLIIKGQ
SQLLENIATI EQLETVRRLF NVLEARDQMI ELLDVTSEAE GVQIFIGTEN KLFGGSGLSM
VISPYQNAEG SIVGAIGVVG PTRINYARII PLVDYTAKLV GRLIG
//
