ID A0A1Q4UPV8_9PROT Unreviewed; 774 AA.
AC A0A1Q4UPV8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OKH87515.1};
GN ORFNames=LF95_12060 {ECO:0000313|EMBL:OKH87515.1};
OS Thalassospira sp. TSL5-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Thalassospiraceae; Thalassospira.
OX NCBI_TaxID=1544451 {ECO:0000313|EMBL:OKH87515.1, ECO:0000313|Proteomes:UP000186302};
RN [1] {ECO:0000313|EMBL:OKH87515.1, ECO:0000313|Proteomes:UP000186302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSL5-1 {ECO:0000313|EMBL:OKH87515.1,
RC ECO:0000313|Proteomes:UP000186302};
RA Zhou H., Wang H.;
RT "Genome sequencing of Thalassospira sp. TSL5-1.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH87515.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JRJD01000003; OKH87515.1; -; Genomic_DNA.
DR RefSeq; WP_073955248.1; NZ_KV880638.1.
DR AlphaFoldDB; A0A1Q4UPV8; -.
DR STRING; 1544451.LF95_12060; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000186302; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 6..189
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 192..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 347..400
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 774 AA; 83541 MW; 1ACE829C7DB72737 CRC64;
MAEIKQVAVI GAGVMGASIA AHIANSGTPV LLLDIVPEGA KNRNAVAEGA VAKMLKTDPA
PFMNKRAAKL ITCGNIEDDM AKLADCDWIV EAVIERLDIK QNLYRKIDEV RKAGSVVSSN
TSTIPLATLI EGMPASFASD FIITHFFNPP RYMRLLELVS SGETNDGVVD MVAAFADEKL
GKTCVVCHDK PGFIANRLGV YWIQAAMVEA MDAKLTVEEA DSVIGRPFGI PKTGVFGLMD
LVGLDLMPHV QSSMAGALPK SDPFHAIYRE SELVSKLIAD GYTGRKGKGG FYRINRADGG
KVKESVNLET GEFAKSEKAR LESVKAAGKD PRALMESGDK GGKYGRAVMA KTLAYAAFIA
EEAAQNIVDV DDAMKLGYNW KTGPFELIDS IGVDALIAML KEDGIAVPPL LERASSKTFY
KVEDGTLHYL GFDGSYQAVT RPEGVLLLED VKRKSERILG NGSASLWDIG DGAVCLEFHT
KMNALDADVM AIVKSAIRTV KKQYKALVIY NEGSNFSAGA NLGLALFAAN IAVWPEIENL
VETGQMTYKA LKYAPFPVVA APSGLALGGG CEIVLHSDAV QAHGETYIGL VEPGVGLVPA
WGGCKEMIRR WHENPKFPKG PMAASAKAFE IISVATVAKS AYEAKENLFL RPDDGITMNR
NRLLFDAKKR ALAMVEGYEP PEEMVYRLPG ESARVAFEMA VDGFYRLGKA TDYDRVVAGE
LATVLAGGDT DVTVELSEDD MLELERESFM RLARNPGTLA RIETMLLTGK PLRN
//
