ID A0A1Q4UYV9_9ACTN Unreviewed; 731 AA.
AC A0A1Q4UYV9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:OKH90790.1};
GN ORFNames=AB852_29880 {ECO:0000313|EMBL:OKH90790.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH90790.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH90790.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH90790.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH90790.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFBV01000010; OKH90790.1; -; Genomic_DNA.
DR RefSeq; WP_073793448.1; NZ_LFBV01000010.1.
DR AlphaFoldDB; A0A1Q4UYV9; -.
DR STRING; 1048205.AB852_29880; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..332
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 711..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 77857 MW; 7321C81367160F8F CRC64;
MFAAIGEFTA RRRKWVVVAA VVFTLFAGVW GTGVFGSFTG GAGFDDPSSE SVQADKVLEG
PLGRESNDLI VLYESDKSGQ SVDEFGPAVK AALDAVPREG IERLDSFWQP GAQGADAYVS
KDRDQTYVTV QFTSDNDQDQ VELLTEIEDR FAAEGTDVRF GGVAAMTQQV NALTGSDIAR
AEMLSVPLLL LLLVLIFRSA IAALLPLAVG TFVALGSFVV LRVLTMFTEI SSTVINVITI
LALGLAIDYA LFMVSRYRDE LRAGADVDEA VRRATATAGR TVAFSGLAVA ISFAGLIVFP
SRFLSSMGYA AVAVVTFAVV GSLFLLPALL RYTGHSIDKW RIPLPGGKKE RPAKPENQGA
WYRTAHAVMR KPLISSFLIV AALVGLGAPL LGVNWARPGE WVLPSGADAK VVSKDLGSEF
PTNPGRIMTT VVRFDGEADR DATSAYAARL GEVDGVASAT PTAFSGDDAR VTIRYTPDPM
STDAGDMVRD IRATEAPPGA QTLTTGMPAS RVDIVGMIGE RLPWMALFVA VVSFLVLFLA
FGSLLLPLKS VVLNLLSLLA TFGAIKWIFQ DGHLSGLLGF EPIGAVDANF PVLVVAIAFG
LAMDYEVFLL SRVREEWEIS GDPIESMALG LQRSAKIITS AALLLVVVVG GFMTSSILFM
KMIGVGLVIA VIVDATIVRG LLVPATMALL GSKAWWAPAP LARWWSRFNL SESSAPPPPA
EPTAARAEAL R
//
