ID A0A1Q4V606_9ACTN Unreviewed; 832 AA.
AC A0A1Q4V606;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Cell division protein FtsK {ECO:0000313|EMBL:OKH93251.1};
GN ORFNames=AB852_17005 {ECO:0000313|EMBL:OKH93251.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH93251.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH93251.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH93251.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH93251.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFBV01000004; OKH93251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4V606; -.
DR STRING; 1048205.AB852_17005; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:OKH93251.1};
KW Cell division {ECO:0000313|EMBL:OKH93251.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000186455};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 479..679
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 207..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 496..503
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 832 AA; 88582 MW; 3C994A2C01210258 CRC64;
MFRGIGRGAK GLDPAHRKDG LALLLLGLSL IVAAGTWSNL RGPVGDLVEM LVTGAFGRLD
LLVPILLAVI AARLIRHPER PEANGRIVIG LSALVIGVLG QVHIACGAPA RSDGMQDIRD
AGGLIGWGAA TPLTYTVTAV LAVPLLVLLT VFGVLVVTAT PVKAVPERLR SLGVRLGLVQ
PGPDDLSDGY DGYGEDDSRY DDQWREALPA RPGRRSAPPE AYDPGQDEDE APVRRRKPRK
GPARPAGDRP QDAVDVAAAA AAALDGAVMH GMPPSPLVAD LTQGVGVERD PEPTPSVPPA
RVKGARIDEP RGTSAVPDLT KSAPEKHREL PPRAEQLQLS GDITYSLPSL DLLERGGPGK
SRSAANDVVV ASLTNVFMEF KVDAAVTGFT RGPTVTRYEV ELGPAVKVER ITALTKNIAY
AVASPDVRII SPIPGKSAVG IEIPNTDREM VNLGDVLRLA DAAEDDHPML VALGKDVEGG
YVMANMAKMP HILVAGATGS GKSSCINCLI TSIMVRATPE DVRMVLVDPK RVELTAYEGI
PHLITPIITN PKRAAEALQW VVREMDLRYD DLAAFGFRHI DDFNAAVRSG KTKAPPGSER
ELKPYPYLLV IVDELADLMM VAPRDVEDSI VRITQLARAA GIHLVLATQR PSVDVVTGLI
KANVPSRLAF ATSSLADSRV ILDQPGAEKL IGKGDGLFLP MGANKPTRMQ GAFVTEAEVA
LVVQHCKDQM APVFRDDVTV GSKQKKEIDE DIGDDLDLLC QAAELVVSTQ FGSTSMLQRK
LRVGFAKAGR LMDLMESRAI VGPSEGSKAR DVLVKADELD GVLAVIRGET QN
//
