ID A0A1Q4V7X2_9ACTN Unreviewed; 398 AA.
AC A0A1Q4V7X2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=AB852_14570 {ECO:0000313|EMBL:OKH93915.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH93915.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH93915.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH93915.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH93915.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFBV01000003; OKH93915.1; -; Genomic_DNA.
DR RefSeq; WP_073788175.1; NZ_LFBV01000003.1.
DR AlphaFoldDB; A0A1Q4V7X2; -.
DR STRING; 1048205.AB852_14570; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF2; ISOCHORISMATE SYNTHASE ENTC; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455}.
FT DOMAIN 122..384
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 398 AA; 40778 MW; BE6A02D303BDAEC6 CRC64;
MSISALVRPR PVHRAADLLA AYLPGSLYFS SPRGTLLADG VHARVRAGGG AQALAAAEAL
DAAATAGVPE PVVAGAVGFN PAAETGLVVP SVVRRADAPA GVRAPEAESG TSWTITPRPE
SARYAESVRR ALELIGRGDL RKVVLARGLE LTADAPVWVP ALLARLVRAD PAAYAFAVDV
TAPGDPAPRT LVGASPELLV SRRGATVVAN PLAGSAPRSG DDALDRERVA RLRESAKDLG
EHAHTAAQVA EVLGRFCADL DVPSGPEVIG TPTMWHLSTR ITGRLADPTD PACSALGLAE
ALHPTPAVCG VPAPGALAAI TDLEPQARGY YAGMVGWTGL DGDGEWAVTI RSAEVCDRTV
RLFAGAGIVA GSDPAAELAE TGAKFRTLLR ALGVEDMA
//
