ID A0A1Q4V8X0_9ACTN Unreviewed; 1472 AA.
AC A0A1Q4V8X0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=AB852_15165 {ECO:0000313|EMBL:OKH94291.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH94291.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH94291.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH94291.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH94291.1}.
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DR EMBL; LFBV01000003; OKH94291.1; -; Genomic_DNA.
DR STRING; 1048205.AB852_15165; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR PIRSF; PIRSF001617; Alpha-AR; 3.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455}.
FT DOMAIN 995..1070
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1472 AA; 158336 MW; 9349ACB334AE03EF CRC64;
MWYACEFGDP TAYNSPVLLR FPRSLDAGLL RRALRHVVAR HESLRTTFAM ADDGRLMLRV
AAEPDFGFAT ATASGEDALT ALTAEFAGRR LDLRSGPLLH VLCVETGTGG TDGADGMART
EGADATSGTE GVGGTGGAGG TALLVNVHHA VFDGFSWSVL LNEWLTLYQD LAAGAEFTPL
PDAPQFREVV TGRTGGPDPQ ASLEHWTKHL AGVPALLDLP LDRPRGPSAA TARAVRTVLT
GAEAGRLRER AAAEGVTPLM ALLAAYAVLL HRHTGQTDLA VGVPVSLRDR AMDQEVIGHL
VNTVVLRHRV TSGDTVRELL ARTRREVLSA MRHKDAAFED VVKAVGSGED GGRSPLFRTM
VTLMPRERRV LGHLGLGVTE WRHVSGAPKY DLALIVEEGA EELGLTFEYD PALFDTATVE
RIVGRFRVLL ADLLDRPGGT VGELRWVPER ELRELAAVWH GPADDRPAKG SVTDLFEERA
ARSPDATAVE TVDGTVLSYR RLNTRANRLA RALRLRGARP GTRVGVLLER GPEAVVALLA
VLKAGASFVP LDPAYPAERV ALMLADSRPR LLLTRGVTDI PCPDGTEVFD LAAEAGRLRE
LDGTDLPERR RPDDEMYVVY TSGSTGRPKG VAIQDFTLTN VAYRQAELSG PRAASRMLQY
MSLSFDVSFE EIFGALCAGA TLVLTDEETR TDLHRLAGYL RERRVARMFL PYVALQELAS
VVVRGNIPLP ELAEVYTTGE QLVVTPALRK MFGRLTDAGL INAYGPSEAH LCTALRLPAD
PSSWPERPSI GHTVGEVRMY VLDGDRRPVP FGVPGELYVG GRVLSPGYLN LPEQTAERYL
PDPYDTTPGA RLYRTGDLVK CTPRDGFTHL GRVDEQIKIR GHRIEPAEVE AVLGDLPSVT
ASAVVAVEHG PGDRRLVAFL RSDPSPGPDG EPEREPDEAA LRRLLGRTLP AYLVPSRFVR
VVQLPTAPSG KTDRAALAVM AAALPPPRGA VTAERPLTET EQGVARVWGE LLGGAGSGPD
DDFFGQGGHS LLAVRLRGRL QEEYGVEVPL SALLSQPTVA GMAARVERAL TGDSGPDDAG
EPDLWADVRL PDSVDVSHGA RPMGPGGART VLLTGVTGFL GVHLLRSLLA AGCVVHCLVR
AGSTEEATRR VLDSARLYRA DEGLDLSRVR AVPGDLSRER FGLADGVYRE LAGQVEAVYH
AAAHINFAAP YASVRPTNVD GFVRVAEFCA DTVLKPLHHM STLAVFSPEG PGGYIDEDTV
PEVAEGLGIG YAQSKWVAER LAMAARERGV PVTVYRIGRI GPDSVSGACR TDDFFWLQIK
SFLQLGLAPE VPGPPVDLLP ADVVADAVVL LSGAEAAFNR TVHVFHPVGM GWDSVFAALE
SLGRAPRMVS ADEWLAALEA GPAEDGDRSL ASLVPLFREG VMELADHSYG NDRTVRLLRD
LGLELPVPEP SWITSMVRYF TETGQVPAPR VP
//
