ID A0A1Q4V9I8_9ACTN Unreviewed; 327 AA.
AC A0A1Q4V9I8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:OKH94467.1};
GN ORFNames=AB852_09265 {ECO:0000313|EMBL:OKH94467.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH94467.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH94467.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH94467.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH94467.1}.
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DR EMBL; LFBV01000002; OKH94467.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4V9I8; -.
DR STRING; 1048205.AB852_09265; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:OKH94467.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:OKH94467.1}.
FT DOMAIN 26..78
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 153..257
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
SQ SEQUENCE 327 AA; 34977 MW; 02C14CA811F1A1A0 CRC64;
MIMPLPEQSS GVPAPVLDRL GAAGYRAMIA GVRLGVFTAL EAGPLSVEEL ATRIGGTPAG
TRSLVNILVA FGYLRHDEDG VTTAAKPGSE DAELFWYETL FEQWADIEDT IRTGTPRRGF
YTWLSERPAL AGRLRRMLAG AAVALADDIA AALPPAATVL DIGGGHGDHT VELCRRRPDV
RVTVFDLPET ITALREDAPR DRVTAQAGDY LTDDLGSGHD LVLLFNVLHG HRPEECRELF
QRAAKSLSPT GSIVILDHDR EPPAGLGPAA AGFLAMFDLT LWQGHGGGVH RYTDLAVWLG
EAGLTESRVV PLAASPLEKL LIAGRPS
//
