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Database: UniProt
Entry: A0A1Q4VA23_9ACTN
LinkDB: A0A1Q4VA23_9ACTN
Original site: A0A1Q4VA23_9ACTN 
ID   A0A1Q4VA23_9ACTN        Unreviewed;       416 AA.
AC   A0A1Q4VA23;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Serine protease {ECO:0000313|EMBL:OKH94684.1};
GN   ORFNames=AB852_10760 {ECO:0000313|EMBL:OKH94684.1};
OS   Streptomyces uncialis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH94684.1, ECO:0000313|Proteomes:UP000186455};
RN   [1] {ECO:0000313|EMBL:OKH94684.1, ECO:0000313|Proteomes:UP000186455}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCA2648 {ECO:0000313|EMBL:OKH94684.1,
RC   ECO:0000313|Proteomes:UP000186455};
RA   Yan X., Huang T., Ge H., Shen B.;
RT   "Cloning and characterization of the uncialamcin biosynthetic gene
RT   cluster.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKH94684.1}.
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DR   EMBL; LFBV01000002; OKH94684.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q4VA23; -.
DR   STRING; 1048205.AB852_10760; -.
DR   Proteomes; UP000186455; Unassembled WGS sequence.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF11; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000186455};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..416
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013338594"
FT   DOMAIN          83..135
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000259|Pfam:PF05922"
FT   DOMAIN          168..399
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        177
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        210
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        362
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   416 AA;  41197 MW;  8B9B17D80BEC991D CRC64;
     MSPTHIPRRG ITVSLCTAVV AALALGALPA TADTVTRTAT ATGTAVNGTF AQGVIQNAGA
     PGAIEGSYVV TLHPSAADAG SKAGRRLAAA YGATIDRTYG AALNGYAVRL PESRAKKFAA
     DPAVASVAQN HLVKASATQF DPPSWGLDRI DQRTLPLDQR YTYPDSAGQG VTAYVIDTGV
     RTTHGDFGGR AAHGYDAIDN DSVAQDGNGH GTHVAGIVAG TRYGVAKKAR VVGVRVLNDA
     GSGTIAQVIA GIDWVTANAV RPAVANLSLG GGANSALDTA VRNSIASGIT YTVAAGGSAA
     DASGFSPARV AEAITVGAAT ITDARAGSSN YGRAVDLFAP GVSITSLWNT GDQATATLSG
     TSMAAPHAAG VAALHLADSP GASPAQVAAT LIATATPGGV GNPGPGSPNR LLYIGP
//
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