ID A0A1Q4VBG3_9ACTN Unreviewed; 1240 AA.
AC A0A1Q4VBG3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ABC transporter {ECO:0000313|EMBL:OKH95040.1};
GN ORFNames=AB852_13025 {ECO:0000313|EMBL:OKH95040.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH95040.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH95040.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH95040.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH95040.1}.
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DR EMBL; LFBV01000002; OKH95040.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4VBG3; -.
DR STRING; 1048205.AB852_13025; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0042883; P:cysteine transport; IEA:InterPro.
DR GO; GO:0034775; P:glutathione transmembrane transport; IEA:InterPro.
DR CDD; cd18584; ABC_6TM_AarD_CydD; 1.
DR CDD; cd03228; ABCC_MRP_Like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR014223; ABC_CydC/D.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014216; ABC_transptr_CydD.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR NCBIfam; TIGR02868; CydC; 1.
DR NCBIfam; TIGR02857; CydD; 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF261; ATP-BINDING_PERMEASE PROTEIN CYDD; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..306
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 338..582
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 673..956
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 990..1229
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 601..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 130358 MW; 4509391A889E2852 CRC64;
MFHVKPIDPR LLRYTRATRG FLLAVVLLGL VGAGLVIAQA TLIAEIVVGA FQEGLSAGEL
RAPLIALAAV AVGRAGVSWL TELAAHRASA AVKSELRGRL LERAGALGPG WLSGQRTGSL
VALATRGIDA LDDYFSRYLP QLGLAVVVPV AVLVRIVTED WVSAAIIAGT LPLIPVFMIL
IGWATQARMD RQWRMLSRLS GHFLDVVAGL PTLKVFGRAK AQAESIRRIT GDYRRATMRT
LRIAFISSFA LELLATLSVA LVAVTIGMRL VHGGMDLSIG LMILILAPEA YLPVRQVGAQ
YHAAAEGLAA AEEVFEVLET EVPTNGTGVL PAGKALGLSF DQVGVRYPGR DDDAVSGVSF
EVGPGETVAL VGPSGAGKST LVAAALGFVR PQRGRVRIGG VDLTGIARES WHQQVAWVPQ
RPHLYAGSVA ENVRLARPDA DDTAVRRALR DAGALEFVDA LPDGASTLLG EDGTGLSAGQ
RQRLALARAF LADRPVLLLD EPTAALDGDT EADVVEAVRR LAVGRTVLLV VHRPALLSVA
DRVVTLAMPE RTVPAQGGTA RTAGTAGVAI AADHGSRRRP TGGDLIAELT DDGAAFGDEL
FQSERDQDRD RERSGDPSHA MDLVGAQAPE RDGDTPVRDG HPGPDGRTGT GARQRSALRR
VRDMAGPRRG RLALALLLGS LALGSAVGLM ATSGYLISRA SQQPPVLYLM MAVTATRTFG
IGRACFRYAE RLVSHDAVLR MLGDTRVAVY RRLERLAPAG LRTTRRGDLL TRLVTDVDAL
QDYWLRWLLP AGAALAVSAG AVGFTAWLLP EAGAVLAVGL LAAGAGVPLL SGAVARRAER
RLAPARGVLA TRVTDLLTGT AELTVAGALP ARTAAARKAD AVLTRIASRA ASATALGDGL
TALVSGLTVA VTALVAARGV ADGRLDGVAM AVVVLTPMAA FEAVMGMPLA VQYRQRVRKS
AERVQEVLDA PAPVREPATP AAAPASPFPL RLEGLRARYD GQRRDALAGV DLTLDEGRRI
AVVGTSGSGK TTLAQVLLRF LDPRPDGTGG TYTLGGVDAH SLDGDTVRGF VGLCAQDAHL
FDSSVRENLL LARRDADDTE LRDVLARVRM LEWADSLPDG LDSLVGEHGA RLSGGQRQRL
ALARALLADF PVLVLDEPAE HLDLPTADAL TADLLAATEG RTTVLITHRL AGLEEVDEVI
VLEAGRIVQR GAFDTLTAAE GPLARMRDRE GAADLLAAAV
//
