ID A0A1Q4VF93_9ACTN Unreviewed; 372 AA.
AC A0A1Q4VF93;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=MerR family transcriptional regulator {ECO:0000313|EMBL:OKH96468.1};
GN ORFNames=AB852_07795 {ECO:0000313|EMBL:OKH96468.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH96468.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH96468.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH96468.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH96468.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFBV01000001; OKH96468.1; -; Genomic_DNA.
DR RefSeq; WP_073784897.1; NZ_LFBV01000001.1.
DR AlphaFoldDB; A0A1Q4VF93; -.
DR STRING; 1048205.AB852_07795; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR CDD; cd01106; HTH_TipAL-Mta; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR30204:SF90; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR TIPA; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000186455}.
FT DOMAIN 4..73
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
SQ SEQUENCE 372 AA; 41525 MW; A791928BE0F374C3 CRC64;
MEEHLSVGRV AGLAGVTVRT LHHYDRIGLV QPSARTPAGY RAYAAGDVER LREVLAYRRL
GFGLREIAEL VDDPATDAVA HLHRLRGLLL EQRDRAAAMV TAIDKELETR AMGKRTTPEE
QLKMFGAQLY ETIGSAYPAT RGTEPRIAAR VWDALGDART VLNVGAGTGS YEPPDRDVTA
VEPSAVMRAQ RPPDAAPCVA AAAEKLPFED GSFDAAMAFS TVHHWRDPIA GLREMRRVAR
RVVVFTHDSS DSGWRQRFWL TRDYLPEITG LVAGRPSVDR LADAIGARRE PVLIPWDCAD
GFLEAYWRRP EAYLEEHVRR AVSVWTRVGP RAEQRAVHRL RDDLSSGRWT ERNRELLALD
TAELGLRLLV AE
//
