ID A0A1Q4VFH5_9ACTN Unreviewed; 742 AA.
AC A0A1Q4VFH5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ATP-dependent DNA helicase {ECO:0000313|EMBL:OKH96567.1};
GN ORFNames=AB852_08445 {ECO:0000313|EMBL:OKH96567.1};
OS Streptomyces uncialis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1048205 {ECO:0000313|EMBL:OKH96567.1, ECO:0000313|Proteomes:UP000186455};
RN [1] {ECO:0000313|EMBL:OKH96567.1, ECO:0000313|Proteomes:UP000186455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCA2648 {ECO:0000313|EMBL:OKH96567.1,
RC ECO:0000313|Proteomes:UP000186455};
RA Yan X., Huang T., Ge H., Shen B.;
RT "Cloning and characterization of the uncialamcin biosynthetic gene
RT cluster.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH96567.1}.
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DR EMBL; LFBV01000001; OKH96567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4VFH5; -.
DR STRING; 1048205.AB852_08445; -.
DR Proteomes; UP000186455; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000186455}.
FT DOMAIN 178..596
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 199..206
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 742 AA; 80428 MW; 71B41D27E3600A9B CRC64;
MRTEQEFVDG LHQRVDLLRS GTERAVAGAL APVGNGLQAR IERDIQVYER SGLLAALDAV
EGSLCFGRID LTSGTVHHIG RIGIRDEDPA TGERVPVLID WRAPVARPFY LATGHTPLGL
RRRRHLTCEG RTVTALHDEI LDLGDTSRTG HEDPTGDAVL LAALDAARTG RMGDIVRTIQ
AGQDRVIRAP HQGVLVIEGG PGTGKTAVAL HRAAYLLYEY RELLAKRAVL IVGPNPAFLG
YIGEVLPALG ETGVLLATVG ELYPGVRATV TDTPRAAEVK GRAEMAGVLA AVVADRQALP
DPAVLIEHDR DILRLDADLV RVARDRTRAL GLPHNAAREH FEGHLLNTLT DLVAERIGTD
PYDGSNLLDP SDLTQIRDEL GADPEVHAVI DTLWPRLTPQ RLLADFLADP THLAPADAAA
VRRTGGDWTT ADVPLLDEAA ELLGEDDRAA RTEAERERLR RIAYAQGVLD VSYASRTYEF
EDVDDEDSEV LGAHDVIDAE RMAERHEEDD HRGAAERAAA DRTWTFGHII VDEAQELSAM
AWRLLMRRSP TRSMTLVGDP AQTADEAGVG SWERILAPYV QDRWEHTVLG VNYRTPAEIM
DAAARVVRAE HPGFEPPESV RSTGAHPWVR ETTPEKLAAT VGDAVAGALP DEGRLAVIAP
RALHPELARS LPGVTAGAAP DLTRRVVLLD PRQSKGLEFD TVIVVEPGEY RTSDLYVAMT
RATQSLGLVH TGHDPLSAAP AG
//
