ID A0A1Q4VIF5_9ACTN Unreviewed; 582 AA.
AC A0A1Q4VIF5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Beta-galactosidase {ECO:0000313|EMBL:OKH97585.1};
GN ORFNames=AMK13_37675 {ECO:0000313|EMBL:OKH97585.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKH97585.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKH97585.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKH97585.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH97585.1}.
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DR EMBL; LIPD01000023; OKH97585.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4VIF5; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 2..313
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 362..473
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 491..549
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 147
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 223
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 582 AA; 63450 MW; C2B0674D412E514D CRC64;
MRGGRPHRIV SAAVHYFRIR PQQWTDRLTR LRAMGVNTVE TYVAWNFHQP APGRADFTGD
RDLAAFVRAA GDLGLDVIVR PGPYICAEWE FGGLPGWLLA DPAMRLRRLD PPFLAAVDAW
FDHLVPVLLP LLSSHGGPVV AVAVENEYGS YGNDTAYLEH LRDALVARGV DVLLFTADGA
EDGFQLGGRV PGLLTTGTFG SRPEESLACL RRHQPVGPLV TMEYWCGWFD HWGAPHHVRD
AEDAAEVLDA QLAAGASVNM YMGHGGTNFG WWNGANHDGT SYQPDVTSYD YDAPVGEAGE
LTEKFHLFRA VIERHLGPNP HPLPPLPARL APRSAPVTAG RPLLGAGGAL GELSTAHRLP
EPLPMERLGQ NLGLIHYRTR LRGPLARGEL RVDGLADRAQ VFLDGEPLGV LDRNHPEQAL
PLRVPEGGAV LELLVENLGR INYGPLLHDP KGITGGVRVD RQYQFGWEIR PLPLDDLTAL
ALGAPSTADG PGFHRAELTV DTPADGFLAL PGFTKGMVWL NGFALGRYWD RGPQRTLYAP
APLWRAGANE LLVLELHRPG DRVELVEGPD LGPAVPEERY GS
//
