ID A0A1Q4VJA4_9ACTN Unreviewed; 2017 AA.
AC A0A1Q4VJA4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:OKH97901.1};
GN ORFNames=AMK13_37420 {ECO:0000313|EMBL:OKH97901.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKH97901.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKH97901.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKH97901.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH97901.1}.
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DR EMBL; LIPD01000022; OKH97901.1; -; Genomic_DNA.
DR RefSeq; WP_074006039.1; NZ_LIPD01000022.1.
DR OrthoDB; 5478077at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..85
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 101..515
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1411..1488
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2017 AA; 215843 MW; AEA905B08EB10BF2 CRC64;
MPHERAARDI TDVTDFLLSR FAELSDVSAA SVDLRAPMHR YGLDSLKSVN LAASLSEYLG
WQVPATWMWQ YPTLDGLARA LVDGPRSAGP APGAERRKPA HEPVAVVGIG CRFPGGPDPS
SFWRLLVEGG DAVGPVPAAR RELLGDRVRW GGFIDGIDRF DPLFFGISPR EAVQMDPQQR
LVLELCWEAL EDAGIAPHSL VGSDTGVFMA SCWNDYAALA HYRGPDAQIT PHTATGIHDG
IIANRVSYVL GLQGPSMAID AACAGSLVSV HVGCQSIQLG ESDLVLAGGV NLSFVPDYYT
AMDQLGAISP DGRCKTFDAR ANGTTRGEGA GVVVLAPLSV ALERDLPVYC LIKGSSSNND
GPSNGMTAPN PQAQEKMLRT AYQRAGIAPD LVDYIECHGT ATPLGDPIEA NAVGAVLGGA
DRAAPLRIGS VKSNVGHLEA AAGIVGLAKL ALSMRNGVLP PSLHYSAPNP QILFDAYNLT
VQDRLTPWPR RSDARRGGVS SFGFGGAICH IAVEELPRPE ASLLLLAADS PAELAERALE
SRDATDLRAL CRRTPGDGPF RLAATARDMA ELRSSLDAFA AGTTAPGLSV GEVGERPGRP
RVAFLFSGNG SQWVGMGRQL LAGRPVFRRS MTRSDRRMRE LLGFSLVEQL MDPDGRLDDM
DVFQPLLFSL QVALAETWRS LGVEPDVVVG QSVGEFAAAH IAGALDFEDA SRLAAHHGRL
LQQLAVGRGE GIVVMTPADE VRPHLTGGLT LSGHNGLSST LVTGTPQEID DLVRRLTDAG
VVNHRVRMGH APHSPLVDHV LAPLKAELDG IRPRTARVPM ISTVTGEPVD GAELGPDYWA
DNLRREIRVV DALTRLRDHD VDAVVELSPH PLLLKSVSEI LPAVTTLPSL RRGADEAATL
LGSLGALYAA GLPVAAHPFL AGDRGRHAVP GGGEAAAADR VHLVPVTART ADALADTCRA
LSNHVERDPA LRVSDLAYTL AARRTHHAHR IALFARDRQD VLDGLARIAD GRPHPDVVTG
TVSGTADRRV ALVFSGTGTH WAGMGRELLR SHAGFRQWMH ACDDAVRAAG GGSVLDRLTA
PDGQARYEEL DVQQPVLFAL QVSLAKVWLG LGVEPAAVVG HSLGEVAAAC VAGALSLEDA
ARVVVARSQL LEHEAAAGAM LSVDLPEPEL LPRLAAYAGQ AAVAAVNSPT STVVSGPREA
LDALAADLGR DGIPARRLRV ERPMHSPGMD ALTGPLRERL KDIAPLAPGL DFHSTALAGA
VNPVVDADYW VRNLRDRVRF AEATAALVDR GVSTFIEIGP HETLRGAVEE TGLSRGVRVH
AVNSMRRGES DLRCLLGAAA ELFVRGLPLT FDPLFGDDVE VVETPLVQWQ KERYWIDSEP
RREPAPVAAA AVAAVAAVAE PVAARPAQAT VAERPVAEVV LAELADALGV PAGRFDAGAG
LRDFGLDSML AIRLVNRMQA VLGHRVSPVV FLDGRSIAEV VGHFVGLADG PAAPAPQPPQ
AVQAPQAVQA VQAVQAPTPK PEPARSFLED LSELDAEELL EELDARGLLE ATDAPAPEQL
RAEGLGLELA PASHGQASLW FMQMIAPDAV PYNYMVTARI RTAVDEDALE RAVLAVLDRH
PALRTLYVEA GGRPYQVVLD EPVYEFLVVD TADLDDEEAR EELARYGHEP LDMDNGPLVR
VVLMRRGPSD HFLMVLVHHI ASDAASADIM IRELQEFYEG ADPAGRTPVA PYTEFVEWER
QWLAGPAAEA ALDWWSEKLA DPPAHLDLSS KERPPGVTYE GRDLAFRWST EETRLLREFA
VREGVSISTV VLAGFFATLN RAAGTEDSVL ATAIAQRAEP GWESAIGYYL NTVLVRANPA
GDRSFRELLR EVHAFSLGLL EHMNYPLDLL AAQLKPPRAE GRSPWFDVVV NWLSSDAFPR
SVKLFHGVGE TLSPDAALPL EPLQVRRHLA KFDLEISMAD IDGRVAGHVQ FKPGYLERQT
VTALLALYRT VLFDSIARPD QALGDIAPAG LPKETEQ
//