ID A0A1Q4VKF9_9ACTN Unreviewed; 382 AA.
AC A0A1Q4VKF9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00012247};
DE EC=3.1.4.46 {ECO:0000256|ARBA:ARBA00012247};
GN ORFNames=A6A06_29370 {ECO:0000313|EMBL:OKH98301.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKH98301.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKH98301.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKH98301.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-
CC glycerol 3-phosphate; Xref=Rhea:RHEA:12969, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:57597,
CC ChEBI:CHEBI:83408; EC=3.1.4.46;
CC Evidence={ECO:0000256|ARBA:ARBA00029315};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH98301.1}.
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DR EMBL; LWKZ01000027; OKH98301.1; -; Genomic_DNA.
DR RefSeq; WP_073767813.1; NZ_LWKZ01000027.1.
DR AlphaFoldDB; A0A1Q4VKF9; -.
DR STRING; 1718985.A6A06_29370; -.
DR OrthoDB; 9758957at2; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08602; GDPD_ScGlpQ1_like; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR43620:SF7; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD6; 1.
DR PANTHER; PTHR43620; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000185893};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 50..376
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 382 AA; 42074 MW; 90436DF7C9DD2F7F CRC64;
MQERQQPGRR TVLGAAALGA GAAVWAGTGT ASAASSRGRG HGPHDELPVP LIVGHRGASG
YRPEHTFGSY QLALDMGADV IEQDVVPTKD GHLVCRHEND ITATTDVSAH PEFADRKTTK
TVDGAKLTGW FTEDFTLAEL KTLRAKERIP GTRQHNTLYD GVWDVPTFEE VLKWADREGR
KRGRRVWLHI ETKHPTYFRK LGLGLEERVA RLLRKYGRHK KHSPNFLQSF EPSSIQRLDQ
LVDCPKVVLL GTLKDRPWDF EVAGDPRTTA DLVKPAGLKW ISGFAQGIGP DLTVILPRTK
DDKLGKPSSV VKDAHAAGLV LHPYTGRNEN TFLPADFRRG TDPNAYGDAL GYFKKCLATG
IDGLFSDNCD TALLAAAEFR GR
//
