ID A0A1Q4VLW9_9ACTN Unreviewed; 791 AA.
AC A0A1Q4VLW9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Macrolide ABC transporter permease {ECO:0000313|EMBL:OKH98786.1};
GN ORFNames=AMK13_35965 {ECO:0000313|EMBL:OKH98786.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKH98786.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKH98786.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKH98786.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC LolC/E subfamily. {ECO:0000256|ARBA:ARBA00005236}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH98786.1}.
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DR EMBL; LIPD01000019; OKH98786.1; -; Genomic_DNA.
DR RefSeq; WP_074005771.1; NZ_LIPD01000019.1.
DR AlphaFoldDB; A0A1Q4VLW9; -.
DR OrthoDB; 3223244at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR025857; MacB_PCD.
DR PANTHER; PTHR30489; LIPOPROTEIN-RELEASING SYSTEM TRANSMEMBRANE PROTEIN LOLE; 1.
DR PANTHER; PTHR30489:SF0; LIPOPROTEIN-RELEASING SYSTEM TRANSMEMBRANE PROTEIN LOLE; 1.
DR Pfam; PF02687; FtsX; 2.
DR Pfam; PF12704; MacB_PCD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 247..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..215
FT /note="MacB-like periplasmic core"
FT /evidence="ECO:0000259|Pfam:PF12704"
FT DOMAIN 250..369
FT /note="ABC3 transporter permease protein"
FT /evidence="ECO:0000259|Pfam:PF02687"
FT DOMAIN 673..789
FT /note="ABC3 transporter permease protein"
FT /evidence="ECO:0000259|Pfam:PF02687"
SQ SEQUENCE 791 AA; 80021 MW; 3F62EA4E904F66E8 CRC64;
MLIVANVRER WSSHLACWLA VLVGVGLITA TLTVHESARP AVQPRLSAAT ALVLPPQATG
RGGSAEDRVP WNAAEAGALT DRLRAAPGVA AAVVDRAFYA QAVRDGRPVP DEGAAEAGHG
WSSARLAPYR LLTGRGPEAA DEVVVDRSLG VPAGARLTVN LTAGRTEFTV VGTVDGPGYY
LSDAAAAQRD PGVRTIALLP APGTPPARLA AAARTAVGDR AAVVTGEGRA ALQPRHVEHR
RFLGTQVIAA LATLGLFTTG FVVASMLVLA TGLRRRELGL LRVLGATPGQ LRRMVLGEAA
LVGLLGSAAG CLAGLAAAPL LRDALLRLDV APPGLTVRVT AWPLLTAAAT GVGVSVLGAW
AASRPAARVA PLQALRESRT GEGQLGRTRL ICGVVVLGLG TGCAVLTATA AADRRISLAI
TATMLLIAAA ALLAPVLVGP VGRVVTAPLR RLGTAGPLLL RAGLTAGASR AAAAAAPVIA
AVGFAVLLSG AVETMRAAYP AGQALRLSGQ AIVTNDGTPG LTDEAADAHP VGKAALPTRA
FVHRADGTTV VIDALGSRDP AWSRPGEAVL GTSMARWLGV TAGQRYPVRF ADGATVPLLI
AGILPDDPAR GDFVLARSLV RGHDPAALGD DLFVPAEADP VAVVPGTAVH DAVRYALDDY
DTDARLTDSL AAMLIAVAVG YSAIATANST ALSAHGRRRD LAVLRSTGGT VRQLVLLAAG
EAAVVTAIGT LLGLLATLPP LAGLASGLAQ STGAPVTLHL DPAALASVVL ACLLLSGTTA
GLVTWRVLRR A
//
