ID A0A1Q4VP56_9ACTN Unreviewed; 413 AA.
AC A0A1Q4VP56;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:OKH99601.1};
GN ORFNames=AMK13_34910 {ECO:0000313|EMBL:OKH99601.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKH99601.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKH99601.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKH99601.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH99601.1}.
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DR EMBL; LIPD01000017; OKH99601.1; -; Genomic_DNA.
DR RefSeq; WP_074005619.1; NZ_LIPD01000017.1.
DR AlphaFoldDB; A0A1Q4VP56; -.
DR OrthoDB; 144122at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06142; RNaseD_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|EMBL:OKH99601.1};
KW Hydrolase {ECO:0000313|EMBL:OKH99601.1};
KW Nuclease {ECO:0000313|EMBL:OKH99601.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 230..310
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 413 AA; 44390 MW; DB367A6F59B49E36 CRC64;
MTDAVAAIPE EAAPVPLLEP REGIPPVVAD EQALGAVVAA FAAGTGPVAV DAERASGYRY
GQRAYLIQLR RAGSGSALID PIACPDLSAL GKAVEDAEWV VHAASQDLPC LSDVGMRPQR
LFDTELAGRI AGFARVGLGP MTENVLGLSL SKEHSAVDWS TRPLPEPWLR YAALDVEVLV
ELRDALEQEL DAQGKLGWAM EEFASIAAAP RPGPRNDPWR RTSQLHKIRR RRQLAVVREL
WLVRDRMAQD RDVSPGRVLA DAAIVNAALA MPLNIAALQA VQGFGPRVHR RQLEQWLAAV
QRAREIPENM LPPATAPHDG PPPPRAWAEK DPVAAARLSG ARAAISELAE RYHVPAENLM
TPDTVRRVCW HPPAEPGPEA VAAALRGFGA RQWQVDLVAP AVAAAFAAAA AQD
//
