ID A0A1Q4VRV6_9ACTN Unreviewed; 381 AA.
AC A0A1Q4VRV6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Stilbene synthase {ECO:0000313|EMBL:OKI00551.1};
GN ORFNames=AMK13_33290 {ECO:0000313|EMBL:OKI00551.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI00551.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI00551.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI00551.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI00551.1}.
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DR EMBL; LIPD01000015; OKI00551.1; -; Genomic_DNA.
DR RefSeq; WP_074005401.1; NZ_LIPD01000015.1.
DR AlphaFoldDB; A0A1Q4VRV6; -.
DR OrthoDB; 9786288at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 85..209
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 266..380
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT REGION 212..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 147
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 381 AA; 40926 MW; C0071CE005F4AC93 CRC64;
MTTALDRAPA ATVPRIVSVG TAVPPEHYSQ EELLDLFGIT DRRVRSVFLL GSIRQRSLVL
PPAAPDGTRL RESQGDLLDK HKAWAVSMGA DALQLCLKRI GADLSEVAYL CCVTSTGFLT
PGLSALLIRE LGMDWHTARA DIVGMGCNAG LNALAVVGNW AAANPGRLAV MVCSEACSAA
YTMDATMRTA VVNSLFGDGA AAVAVVADPV NDGRRPAEGA EDEEAEEEGP GRRLEGPRIL
RTASVTIVDA IDAMRYDWDR DQGRFSFFLD PQVPYLVGAH VEGVVDRLLA GTSLRRDDVA
HWLVHSGGKK VIDAVAVNLG LTRHDLRHTI TVLRDFGNVS SGSFLFSYDR LLREGVVRDG
DYGVLMTMGP GSTIESALIQ W
//
