ID A0A1Q4VSC2_9ACTN Unreviewed; 514 AA.
AC A0A1Q4VSC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA polymerase subunit sigma-70 {ECO:0008006|Google:ProtNLM};
GN ORFNames=A6A06_17340 {ECO:0000313|EMBL:OKI00706.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI00706.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI00706.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI00706.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC {ECO:0000256|ARBA:ARBA00010641}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI00706.1}.
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DR EMBL; LWKZ01000024; OKI00706.1; -; Genomic_DNA.
DR RefSeq; WP_073763452.1; NZ_LWKZ01000024.1.
DR AlphaFoldDB; A0A1Q4VSC2; -.
DR STRING; 1718985.A6A06_17340; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 1.10.10.1320; Anti-sigma factor, zinc-finger domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041916; Anti_sigma_zinc_sf.
DR InterPro; IPR039425; RNA_pol_sigma-70-like.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR027383; Znf_put.
DR PANTHER; PTHR43133:SF58; BLL3014 PROTEIN; 1.
DR PANTHER; PTHR43133; RNA POLYMERASE ECF-TYPE SIGMA FACTO; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF13490; zf-HC2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000185893};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 19..77
FT /note="RNA polymerase sigma-70 region 2"
FT /evidence="ECO:0000259|Pfam:PF04542"
FT DOMAIN 194..228
FT /note="Putative zinc-finger"
FT /evidence="ECO:0000259|Pfam:PF13490"
FT REGION 90..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..493
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 51529 MW; 9E430BDC9E2DCA96 CRC64;
MSEVSAESPA SAADDYTRLY EREHPRLVAY ARSLTTSAWL AEDLVAEAHF RVWRRIRSGH
RIDNVPAYLR TTIRHLASAV GAAAAREIPQ DPEDGPAWPG TGPAWPGSSP AAEQADPAQR
VAYVDLLARV MGRLPQRWVT ALWLAEAEDQ PLEEVGRAIG AGKGATAVLL HRAREGMRQA
FLGSVPGTPD DPACEVHWRR MPAFVRGEAT AKQADGVAGH LAGCPDCRAR MALLTRANDR
LPALTGPALL VLLAGGSAKF LLPLAGAGAA AAGGHAAGSG AAASVQHALT SVPRSVRQLL
RGQIGQAGPV AATVAGVGVA VVAGVAVAAG VALTGGDASP AAERTAAAPG ESGSGGAGRA
APDATADRSA TSAPTGAPDA PPAPAARGTA SAPPAPRAGA PAASQAPAPS ASQAPAPSGT
GRPGPTPAPT GPATSPGPDP TASAPTGGPT RPTAVPTPVP TGSPTARPTP TPTPSPTITP
TITPTPTPTP TPSPSEHCHW GWWGWGPVWI CRTG
//
